The treatment of oral leukoplakia with the CO<inf>2</inf> laser: A retrospective study of 65 patients

Alfonso Mogedas-Vegara, Juan Antonio Hueto-Madrid, Eduardo Chimenos-Küstner, Coro Bescós-Atín

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    16 Citations (Scopus)

    Abstract

    © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. The use of CO2 laser has become a routine procedure for the treatment of oral leukoplakia. In this retrospective study, we evaluated 65 patients with oral leukoplakia treated with CO2 laser vaporization. The main location was the tongue (n = 21/65, 32.3%). The initial biopsy showed mild/moderate dysplasia in almost half the patients (n = 29, 44.6%) and hyperplasia without dysplasia in around a third of the patients (n = 21, 32.3%). The recurrence and malignant transformation rates were 33.8% (n = 22) and 15.4% (n = 10), respectively. The follow-up mean (standard deviation) was 15.0 (10.6) months. The procedure-related complications rate was 7.7% (n = 5). The Kaplan-Meier curves for time to recurrence showed differences only for gingiva lesions compared to tongue lesions (log rank, p = 0.032). Malignant leukoplakia transformation is independent of treatment, although it seems advisable to treat leukoplakia with or without dysplasia.
    Original languageEnglish
    Pages (from-to)677-681
    JournalJournal of Cranio-Maxillofacial Surgery
    Volume43
    Issue number5
    DOIs
    Publication statusPublished - 1 Jun 2015

    Keywords

    • CO laser 2
    • Malignant transformation
    • Oral dysplasia
    • Oral leukoplakia
    • Potentially malignant oral disorder
    • Recurrence

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