Abstract
Several polymorphisms in the apolipoprotein E (APOE) promoter region have been recently described. Of interest, APOE gene expression is increased in association with the -491AT polymorphism T-allele and decreased in relation to the Th1/E47cs polymorphism G-allele. In the present study we have investigated both polymorphisms in a series of 183 Alzheimer disease (AD) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in APOE homozygous individuals. Subsequently, the associations among APOE promoter polymorphisms, APOE4, and AD were assessed by chi-square and logistic regression analyses. Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 187-190 |
Journal | Neuroscience Letters |
Volume | 326 |
DOIs | |
Publication status | Published - 5 Jul 2002 |
Keywords
- -491AT polymorphism
- Age-at-onset/age
- Alzheimer disease
- Apolipoprotein E
- Apolipoprotein E promoter
- Risk factor
- Th1/E47cs polymorphism