The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

Katrin Beyer; José I. Lao; Milagros Gómez; Nadal Riutort; Pilar Latorre; José L. Mate; Aurelio Ariza

doi:https://doi.org/10.1016/S0304-3940(02)00355-5

The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

Katrin Beyer, José I. Lao, Milagros Gómez, Nadal Riutort, Pilar Latorre, José L. Mate, Aurelio Ariza

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Several polymorphisms in the apolipoprotein E (APOE) promoter region have been recently described. Of interest, APOE gene expression is increased in association with the -491AT polymorphism T-allele and decreased in relation to the Th1/E47cs polymorphism G-allele. In the present study we have investigated both polymorphisms in a series of 183 Alzheimer disease (AD) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in APOE homozygous individuals. Subsequently, the associations among APOE promoter polymorphisms, APOE4, and AD were assessed by chi-square and logistic regression analyses. Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	187-190
Journal	Neuroscience Letters
Volume	326
DOIs	https://doi.org/10.1016/S0304-3940(02)00355-5
Publication status	Published - 5 Jul 2002

Keywords

-491AT polymorphism
Age-at-onset/age
Alzheimer disease
Apolipoprotein E
Apolipoprotein E promoter
Risk factor
Th1/E47cs polymorphism

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title = "The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset",

abstract = "Several polymorphisms in the apolipoprotein E (APOE) promoter region have been recently described. Of interest, APOE gene expression is increased in association with the -491AT polymorphism T-allele and decreased in relation to the Th1/E47cs polymorphism G-allele. In the present study we have investigated both polymorphisms in a series of 183 Alzheimer disease (AD) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in APOE homozygous individuals. Subsequently, the associations among APOE promoter polymorphisms, APOE4, and AD were assessed by chi-square and logistic regression analyses. Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele. {\textcopyright} 2002 Elsevier Science Ireland Ltd. All rights reserved.",

keywords = "-491AT polymorphism, Age-at-onset/age, Alzheimer disease, Apolipoprotein E, Apolipoprotein E promoter, Risk factor, Th1/E47cs polymorphism",

author = "Katrin Beyer and Lao, {Jos{\'e} I.} and Milagros G{\'o}mez and Nadal Riutort and Pilar Latorre and Mate, {Jos{\'e} L.} and Aurelio Ariza",

year = "2002",

month = jul,

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doi = "https://doi.org/10.1016/S0304-3940(02)00355-5",

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pages = "187--190",

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The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset. / Beyer, Katrin; Lao, José I.; Gómez, Milagros; Riutort, Nadal; Latorre, Pilar; Mate, José L.; Ariza, Aurelio.

In: Neuroscience Letters, Vol. 326, 05.07.2002, p. 187-190.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

AU - Beyer, Katrin

AU - Lao, José I.

AU - Gómez, Milagros

AU - Riutort, Nadal

AU - Latorre, Pilar

AU - Mate, José L.

AU - Ariza, Aurelio

PY - 2002/7/5

Y1 - 2002/7/5

N2 - Several polymorphisms in the apolipoprotein E (APOE) promoter region have been recently described. Of interest, APOE gene expression is increased in association with the -491AT polymorphism T-allele and decreased in relation to the Th1/E47cs polymorphism G-allele. In the present study we have investigated both polymorphisms in a series of 183 Alzheimer disease (AD) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in APOE homozygous individuals. Subsequently, the associations among APOE promoter polymorphisms, APOE4, and AD were assessed by chi-square and logistic regression analyses. Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

AB - Several polymorphisms in the apolipoprotein E (APOE) promoter region have been recently described. Of interest, APOE gene expression is increased in association with the -491AT polymorphism T-allele and decreased in relation to the Th1/E47cs polymorphism G-allele. In the present study we have investigated both polymorphisms in a series of 183 Alzheimer disease (AD) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in APOE homozygous individuals. Subsequently, the associations among APOE promoter polymorphisms, APOE4, and AD were assessed by chi-square and logistic regression analyses. Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

KW - -491AT polymorphism

KW - Age-at-onset/age

KW - Alzheimer disease

KW - Apolipoprotein E

KW - Apolipoprotein E promoter

KW - Risk factor

KW - Th1/E47cs polymorphism

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DO - https://doi.org/10.1016/S0304-3940(02)00355-5

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SP - 187

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