The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

Katrin Beyer, José I. Lao, Milagros Gómez, Nadal Riutort, Pilar Latorre, José L. Mate, Aurelio Ariza

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9 Citations (Scopus)

Abstract

Several polymorphisms in the apolipoprotein E (APOE) promoter region have been recently described. Of interest, APOE gene expression is increased in association with the -491AT polymorphism T-allele and decreased in relation to the Th1/E47cs polymorphism G-allele. In the present study we have investigated both polymorphisms in a series of 183 Alzheimer disease (AD) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in APOE homozygous individuals. Subsequently, the associations among APOE promoter polymorphisms, APOE4, and AD were assessed by chi-square and logistic regression analyses. Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)187-190
JournalNeuroscience Letters
Volume326
DOIs
Publication statusPublished - 5 Jul 2002

Keywords

  • -491AT polymorphism
  • Age-at-onset/age
  • Alzheimer disease
  • Apolipoprotein E
  • Apolipoprotein E promoter
  • Risk factor
  • Th1/E47cs polymorphism

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