The structure of histone H1 and its location in chromatin

J. Allan, P. G. Hartman, C. Crane-robinson, F. X. Aviles

Research output: Contribution to journalArticleResearchpeer-review

520 Citations (Scopus)


On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into three distinct domains. Only the central domain (∼80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds to the segment of highest sequence conservation. Without the flanking domains it is able to close two full turns of DNA in the nucleosome and can thus locate the H1 molecule. © 1980 Nature Publishing Group.
Original languageEnglish
Pages (from-to)675-679
Issue number5792
Publication statusPublished - 1 Dec 1980


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