The standard electrode potential (E θ) predicts the prooxidant activity and the acute toxicity of metal ions

Thomas B. Kinraide, Charlotte Poschenrieder, Peter M. Kopittke

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

The standard electrode potential (E θ) has been known for many decades to predict the toxicity of metal ions. We have compiled acute toxicity data from fifteen studies and find that the toxicity of thirty metal ions correlates with E θ at r 2 = 0.868 when toxicity is expressed as log concentration of comparably effective doses. We have discovered an even stronger relationship between the prooxidant activity (PA) of metal ions and E θ (and electronegativity, χ). Data compiled from thirty-four studies demonstrate that the PA of twenty-five metal ions correlates with E θ at r 2 = 0.983 (and χ at r 2 = 0.968). PA was commonly measured as metal-induced peroxidation of cell membranes or accumulation of reactive oxygen species. None of the redox metals (capable of Fenton-like reactions) in our studies (i.e., Mn, Fe, Co, Ni, and Cu) was prooxidative or toxic beyond what was expected from E θ or χ. We propose that the formation of superoxide-metal ion complexes is greater at greater E θ or χ values and that these complexes, whether free or enzyme-bound, function in PA without redox cycling of the complexed ion. © 2011 Elsevier Inc.
Original languageEnglish
Pages (from-to)1438-1445
JournalJournal of Inorganic Biochemistry
Volume105
Issue number11
DOIs
Publication statusPublished - 1 Nov 2011

Keywords

  • Electronegativity
  • Metal ion
  • Prooxidant
  • Standard electrode potential
  • Superoxide
  • Toxicity

Fingerprint Dive into the research topics of 'The standard electrode potential (E <sup>θ</sup>) predicts the prooxidant activity and the acute toxicity of metal ions'. Together they form a unique fingerprint.

Cite this