The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

Angela Sanabria; Montserrat Alegret; Octavio Rodriguez-Gomez; Sergi Valero; Oscar Sotolongo-Grau; Gemma Monté-Rubio; Carla Abdelnour; Ana Espinosa; Gemma Ortega; Alba Perez-Cordon; Anna Gailhajanet; Isabel Hernandez; Maitee Rosende-Roca; Liliana Vargas; Ana Mauleon; Domingo Sanchez; Elvira Martin; Dorene M. Rentz; Francisco Lomeña; Agustin Ruiz; Lluis Tarraga; Merce Boada; N. Aguilera; M. Berthier; M. Buendia; S. Bullich; F. Campos; P. Cañabate; C. Cuevas; I. De Rojas; S. Diego; S. Gil; J. Giménez; R. Gismondi; M. Gómez-Chiari; M. Guitart; B. Hernández-Olasagarre; M. Ibarria; A. Lafuente; J. Martínez; M. Moreno; S. Moreno-Grau; L. Núñez; A. Orellana; A. Páez; A. Pancho; J. Pavía; E. Pelejà; V. Pérez-Grijalba; P. Pesini; S. Preckler; J. Romero; S. Ruiz; M. Santos; M. Sarasa; M. A. Tejero; M. Torres; A. Vivas

doi:10.1038/s41598-018-21644-y

The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

Angela Sanabria, Montserrat Alegret, Octavio Rodriguez-Gomez, Sergi Valero, Oscar Sotolongo-Grau, Gemma Monté-Rubio, Carla Abdelnour, Ana Espinosa, Gemma Ortega, Alba Perez-Cordon, Anna Gailhajanet, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Ana Mauleon, Domingo Sanchez, Elvira Martin, Dorene M. Rentz, Francisco Lomeña, Agustin RuizLluis Tarraga, Merce Boada, N. Aguilera, M. Berthier, M. Buendia, S. Bullich, F. Campos, P. Cañabate, C. Cuevas, I. De Rojas, S. Diego, S. Gil, J. Giménez, R. Gismondi, M. Gómez-Chiari, M. Guitart, B. Hernández-Olasagarre, M. Ibarria, A. Lafuente, J. Martínez, M. Moreno, S. Moreno-Grau, L. Núñez, A. Orellana, A. Páez, A. Pancho, J. Pavía, E. Pelejà, V. Pérez-Grijalba, P. Pesini, S. Preckler, J. Romero, S. Ruiz, M. Santos, M. Sarasa, M. A. Tejero, M. Torres, A. Vivas

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Abstract

© 2018 The Author(s). The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.

Original language	English
Article number	3828
Journal	Scientific Reports
Volume	8
DOIs	https://doi.org/10.1038/s41598-018-21644-y
Publication status	Published - 1 Dec 2018

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10.1038/s41598-018-21644-y

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Sanabria, A., Alegret, M., Rodriguez-Gomez, O., Valero, S., Sotolongo-Grau, O., Monté-Rubio, G., Abdelnour, C., Espinosa, A., Ortega, G., Perez-Cordon, A., Gailhajanet, A., Hernandez, I., Rosende-Roca, M., Vargas, L., Mauleon, A., Sanchez, D., Martin, E., Rentz, D. M., Lomeña, F., ... Vivas, A. (2018). The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline. Scientific Reports, 8, [3828]. https://doi.org/10.1038/s41598-018-21644-y

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title = "The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline",

abstract = "{\textcopyright} 2018 The Author(s). The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.",

author = "Angela Sanabria and Montserrat Alegret and Octavio Rodriguez-Gomez and Sergi Valero and Oscar Sotolongo-Grau and Gemma Mont{\'e}-Rubio and Carla Abdelnour and Ana Espinosa and Gemma Ortega and Alba Perez-Cordon and Anna Gailhajanet and Isabel Hernandez and Maitee Rosende-Roca and Liliana Vargas and Ana Mauleon and Domingo Sanchez and Elvira Martin and Rentz, {Dorene M.} and Francisco Lome{\~n}a and Agustin Ruiz and Lluis Tarraga and Merce Boada and N. Aguilera and M. Berthier and M. Buendia and S. Bullich and F. Campos and P. Ca{\~n}abate and C. Cuevas and {De Rojas}, I. and S. Diego and S. Gil and J. Gim{\'e}nez and R. Gismondi and M. G{\'o}mez-Chiari and M. Guitart and B. Hern{\'a}ndez-Olasagarre and M. Ibarria and A. Lafuente and J. Mart{\'i}nez and M. Moreno and S. Moreno-Grau and L. N{\'u}{\~n}ez and A. Orellana and A. P{\'a}ez and A. Pancho and J. Pav{\'i}a and E. Pelej{\`a} and V. P{\'e}rez-Grijalba and P. Pesini and S. Preckler and J. Romero and S. Ruiz and M. Santos and M. Sarasa and Tejero, {M. A.} and M. Torres and A. Vivas",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41598-018-21644-y",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

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Sanabria, A, Alegret, M, Rodriguez-Gomez, O, Valero, S, Sotolongo-Grau, O, Monté-Rubio, G, Abdelnour, C, Espinosa, A, Ortega, G, Perez-Cordon, A, Gailhajanet, A, Hernandez, I, Rosende-Roca, M, Vargas, L, Mauleon, A, Sanchez, D, Martin, E, Rentz, DM, Lomeña, F, Ruiz, A, Tarraga, L, Boada, M, Aguilera, N, Berthier, M, Buendia, M, Bullich, S, Campos, F, Cañabate, P, Cuevas, C, De Rojas, I, Diego, S, Gil, S, Giménez, J, Gismondi, R, Gómez-Chiari, M, Guitart, M, Hernández-Olasagarre, B, Ibarria, M, Lafuente, A, Martínez, J, Moreno, M, Moreno-Grau, S, Núñez, L, Orellana, A, Páez, A, Pancho, A, Pavía, J, Pelejà, E, Pérez-Grijalba, V, Pesini, P, Preckler, S, Romero, J, Ruiz, S, Santos, M, Sarasa, M, Tejero, MA, Torres, M & Vivas, A 2018, 'The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline', Scientific Reports, vol. 8, 3828. https://doi.org/10.1038/s41598-018-21644-y

TY - JOUR

T1 - The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

AU - Sanabria, Angela

AU - Alegret, Montserrat

AU - Rodriguez-Gomez, Octavio

AU - Valero, Sergi

AU - Sotolongo-Grau, Oscar

AU - Monté-Rubio, Gemma

AU - Abdelnour, Carla

AU - Espinosa, Ana

AU - Ortega, Gemma

AU - Perez-Cordon, Alba

AU - Gailhajanet, Anna

AU - Hernandez, Isabel

AU - Rosende-Roca, Maitee

AU - Vargas, Liliana

AU - Mauleon, Ana

AU - Sanchez, Domingo

AU - Martin, Elvira

AU - Rentz, Dorene M.

AU - Lomeña, Francisco

AU - Ruiz, Agustin

AU - Tarraga, Lluis

AU - Boada, Merce

AU - Aguilera, N.

AU - Berthier, M.

AU - Buendia, M.

AU - Bullich, S.

AU - Campos, F.

AU - Cañabate, P.

AU - Cuevas, C.

AU - De Rojas, I.

AU - Diego, S.

AU - Gil, S.

AU - Giménez, J.

AU - Gismondi, R.

AU - Gómez-Chiari, M.

AU - Guitart, M.

AU - Hernández-Olasagarre, B.

AU - Ibarria, M.

AU - Lafuente, A.

AU - Martínez, J.

AU - Moreno, M.

AU - Moreno-Grau, S.

AU - Núñez, L.

AU - Orellana, A.

AU - Páez, A.

AU - Pancho, A.

AU - Pavía, J.

AU - Pelejà, E.

AU - Pérez-Grijalba, V.

AU - Pesini, P.

AU - Preckler, S.

AU - Romero, J.

AU - Ruiz, S.

AU - Santos, M.

AU - Sarasa, M.

AU - Tejero, M. A.

AU - Torres, M.

AU - Vivas, A.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - © 2018 The Author(s). The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.

AB - © 2018 The Author(s). The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.

U2 - 10.1038/s41598-018-21644-y

DO - 10.1038/s41598-018-21644-y

M3 - Article

C2 - 29491481

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 3828

ER -

The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

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