The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

Angela Sanabria, Montserrat Alegret, Octavio Rodriguez-Gomez, Sergi Valero, Oscar Sotolongo-Grau, Gemma Monté-Rubio, Carla Abdelnour, Ana Espinosa, Gemma Ortega, Alba Perez-Cordon, Anna Gailhajanet, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Ana Mauleon, Domingo Sanchez, Elvira Martin, Dorene M. Rentz, Francisco Lomeña, Agustin RuizLluis Tarraga, Merce Boada, N. Aguilera, M. Berthier, M. Buendia, S. Bullich, F. Campos, P. Cañabate, C. Cuevas, I. De Rojas, S. Diego, S. Gil, J. Giménez, R. Gismondi, M. Gómez-Chiari, M. Guitart, B. Hernández-Olasagarre, M. Ibarria, A. Lafuente, J. Martínez, M. Moreno, S. Moreno-Grau, L. Núñez, A. Orellana, A. Páez, A. Pancho, J. Pavía, E. Pelejà, V. Pérez-Grijalba, P. Pesini, S. Preckler, J. Romero, S. Ruiz, M. Santos, M. Sarasa, M. A. Tejero, M. Torres, A. Vivas

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Abstract

© 2018 The Author(s). The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.
Original languageEnglish
Article number3828
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 1 Dec 2018

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