The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo

Laura Cabana, Maxime Bourgognon, Julie T.W. Wang, Andrea Protti, Rebecca Klippstein, Rafael T.M. De Rosales, Ajay M. Shah, Josep Fontcuberta, Ester Tobías-Rossell, Jane K. Sosabowski, Khuloud T. Al-Jamal, Gerard Tobias

    Research output: Contribution to journalArticleResearchpeer-review

    14 Citations (Scopus)

    Abstract

    © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.
    Original languageEnglish
    Pages (from-to)2893-2905
    JournalSmall
    Volume12
    Issue number21
    DOIs
    Publication statusPublished - 1 Jun 2016

    Keywords

    • carbon nanotubes
    • dual-imaging
    • MRI
    • shortening
    • SPECT

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