The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo

Laura Cabana; Maxime Bourgognon; Julie T.W. Wang; Andrea Protti; Rebecca Klippstein; Rafael T.M. De Rosales; Ajay M. Shah; Josep Fontcuberta; Ester Tobías-Rossell; Jane K. Sosabowski; Khuloud T. Al-Jamal; Gerard Tobias

doi:10.1002/smll.201502721

The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo

Laura Cabana, Maxime Bourgognon, Julie T.W. Wang, Andrea Protti, Rebecca Klippstein, Rafael T.M. De Rosales, Ajay M. Shah, Josep Fontcuberta, Ester Tobías-Rossell, Jane K. Sosabowski, Khuloud T. Al-Jamal, Gerard Tobias

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Abstract

© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.

Original language	English
Pages (from-to)	2893-2905
Journal	Small
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/smll.201502721
Publication status	Published - 1 Jun 2016

Keywords

carbon nanotubes
dual-imaging
MRI
shortening
SPECT

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10.1002/smll.201502721

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Cabana, L., Bourgognon, M., Wang, J. T. W., Protti, A., Klippstein, R., De Rosales, R. T. M., Shah, A. M., Fontcuberta, J., Tobías-Rossell, E., Sosabowski, J. K., Al-Jamal, K. T., & Tobias, G. (2016). The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo. Small, 12(21), 2893-2905. https://doi.org/10.1002/smll.201502721

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title = "The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo",

abstract = "{\textcopyright} 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.",

keywords = "carbon nanotubes, dual-imaging, MRI, shortening, SPECT",

author = "Laura Cabana and Maxime Bourgognon and Wang, {Julie T.W.} and Andrea Protti and Rebecca Klippstein and {De Rosales}, {Rafael T.M.} and Shah, {Ajay M.} and Josep Fontcuberta and Ester Tob{\'i}as-Rossell and Sosabowski, {Jane K.} and Al-Jamal, {Khuloud T.} and Gerard Tobias",

year = "2016",

month = jun,

day = "1",

doi = "10.1002/smll.201502721",

language = "English",

volume = "12",

pages = "2893--2905",

journal = "Small",

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Cabana, L, Bourgognon, M, Wang, JTW, Protti, A, Klippstein, R, De Rosales, RTM, Shah, AM, Fontcuberta, J, Tobías-Rossell, E, Sosabowski, JK, Al-Jamal, KT & Tobias, G 2016, 'The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo', Small, vol. 12, no. 21, pp. 2893-2905. https://doi.org/10.1002/smll.201502721

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T1 - The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo

AU - Cabana, Laura

AU - Bourgognon, Maxime

AU - Wang, Julie T.W.

AU - Protti, Andrea

AU - Klippstein, Rebecca

AU - De Rosales, Rafael T.M.

AU - Shah, Ajay M.

AU - Fontcuberta, Josep

AU - Tobías-Rossell, Ester

AU - Sosabowski, Jane K.

AU - Al-Jamal, Khuloud T.

AU - Tobias, Gerard

PY - 2016/6/1

Y1 - 2016/6/1

N2 - © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.

AB - © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.

KW - carbon nanotubes

KW - dual-imaging

KW - MRI

KW - shortening

KW - SPECT

U2 - 10.1002/smll.201502721

DO - 10.1002/smll.201502721

M3 - Article

SN - 1613-6810

VL - 12

SP - 2893

EP - 2905

JO - Small

JF - Small

IS - 21

ER -

The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties in Vitro and in Vivo

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Keywords

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