The Search for Biochemical Photoprobes. IV. The Photoreactions of 2,6-Difluoro-4-nitroanisole with Nucleophiles

Francisco Casado, Maria Cervera, Jordi Marquet, Marcial Moreno-Mañas

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

The photoreactivity of 2,6-difluoro-4-nitroanisole in the presence of nucleophiles suggests that 2,6-difluoro-4-nitrophenyl ethers can constitute improved biochemical photoprobes for use in photoaffinity labeling reagents, specially for proteins where a number of good nucleophiles are present. Almost no photoreduction processes are observed, and one of the fluorine atoms is never replaced. This would allow the detection of the labeled fragments in a photoaffinity labeling experiment by simple NMR methods. © 1995.
Original languageEnglish
Pages (from-to)6557-6564
JournalTetrahedron
Volume51
Issue number23
DOIs
Publication statusPublished - 5 Jun 1995

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