Abstract
Patterns of reversion produced by ciprofioxacin, enoxacin and ofloxacin in Salmonella typhimurium strains carrying the hisG428 ochre mutation have been studied. These fluorinated quinolones produce a significant increase in reversion of this mutation, even when it is located on the chromosome. Nevertheless, reversion is higher when the hisG428 mutation is on the multicopy plasmid pAQ1 than when it is on the chromosome. Reversion of hisG428 induced by fluorinated quinolones is abolished both in a uvrB genetic background and in the absence of the plasmid pKM101. Therefore, mutagenesis produced by fluorinated quinolones in the Salmonella mutagenicity assay is significantly affected by both the excision repair and the error-prone repair systems. Furthermore, fluorinated quinolones are also detected as moderate mutagens with the base substitution hisG46 mutation when both repair systems are functional in the tester strain. © 1992.
Original language | English |
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Pages (from-to) | 207-213 |
Journal | Mutation Research Letters |
Volume | 281 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 1992 |
Keywords
- Fluorinated quinolones
- Mutagenesis
- pKM101
- Salmonella typhimurium
- system