The risk of hemorrhage in long-term treatment with aspirin and triflusal

J. Álvarez Sabín, J. Matías-Guiu, L. Galiano, A. Codina Puiggrós

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6 Citations (Scopus)


Introduction. Different studies have shown that aspirin (AAS), in low doses, may lead to a considerable frequency of hemorrhagic complications when used in the long term. Objective. We compare the long-term occurrence of hemorrhagic complications with low doses of AAS and high doses of triflusal. Patients and methods. Our series included 106 patients who took 900 mg triflusal per day (300 mg 3 times per day) and 111 who took AAS (330 mg/day once daily). The former were followed up for an average period of 48.3 months (20-94) and the latter for 46.3 months (2-84). The average follow-up period for the study was 47.3 months. The presence of hemorrhagic complications was evaluated, as was their frequency and follow-up curve. Results. Compared with AAS, triflusal led to a 76% reduction in risk of hemorrhagic complications (2.8% against 10.8%; OR 0.24; IC 0.06-0.94). There was a slightly increased incidence of hemorrhages in the women's group. There were more hemorrhages than gastrointestinal hemorrhages (4.5% against 0.9%) and intracranial hemorrhages (1.8%-0.9%). The follow-up curve showed significant differences in the form of an increased risk of hemorrhagic complications with AAS. Conclusions. The risk of hemorrhage with AAS depended on the period of follow-up, in a similar manner to with oral anticoagulant agents, in patients with prophylaxis of cerebral infarct. On the other hand, this did not occur with triflusal, with which the risk was homogeneous and lower in the long term.
Original languageEnglish
Pages (from-to)951-955
JournalRevista de Neurologia
Issue number160
Publication statusPublished - 1 Dec 1998


  • Antiplatelet agents
  • Aspirin
  • Intracerebral hemorrage
  • Stroke
  • Triflusal


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