The respiratory virome in chronic obstructive pulmonary disease

Marian Garcia-Nuñez, Miguel Gallego, Concepción Monton, Silvia Capilla, Laura Millares, Xavier Pomares, Mateu Espasa, Rafaella Ferrari, Andres Moya, Eduard Monsó, Vicente Perez-Brocal

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

© 2018 2018 Future Medicine Ltd. Aim: To characterize the respiratory virome in moderate/severe chronic obstructive pulmonary disease (COPD) patients using metagenomics, with healthy subjects as the reference. Patients & Methods: Sputum COPD samples were collected during stability and exacerbations with negative usual-care microbiologic analysis. Results: Eukaryotic viruses from the Anelloviridae, Herpesviridae and Retroviridae families and phages from the Shiphoviridae family were commonly found in COPD, and the respiratory virome in stability and noninfectious exacerbations showed a substantial similarity. DNA viruses with the highest relative abundance in COPD are Anelloviridae. Conclusion: These results support a colonizing role for eukaryotic viruses in COPD and highlight the importance of analyzing both DNA and RNA viruses when focusing on the respiratory virome.
Original languageEnglish
Pages (from-to)457-466
JournalFuture Virology
Volume13
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Chronic obstructive disease
  • metagenomics
  • virome

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