The RENEB operational basis: complement of established biodosimetric assays

Andrzej Wojcik, Ursula Oestreicher, Lleonard Barrios, Anne Vral, Georgia Terzoudi, Elizabeth Ainsbury, Kai Rothkamm, Francois Trompier, Ulrike Kulka

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Purpose: To set up an operational basis of the Realizing the European Network of Biodosimetry (RENEB) network within which the application of seven established biodosimetric tools (the dicentric assay, the FISH assay, the micronucleus assay, the PCC assay, the gamma-H2AX assay, electron paramagnetic resonance and optically stimulated luminescence) will be compared and standardized among the participating laboratories. Methodology: Two intercomparisons were organized where blood samples and smartphone components were irradiated, coded and sent out to participating laboratories for dosimetric analysis. Moreover, an accident exercise was organized during which each RENEB partner had the chance to practice the procedure of activating the network and to handle large amounts of dosimetric results. Results: All activities were carried out as planned. Overall, the precision of dose estimates improved between intercomparisons 1 and 2, clearly showing the value of running such regular activities. Conclusions: The RENEB network is fully operational and ready to act in case of a major radiation emergency. Moreover, the high capacity for analyzing radiation-induced damage in cells and personal electronic devices makes the network suitable for large-scale analyses of low doses effects, where high numbers of samples must be scored in order to detect weak effects.
Original languageEnglish
Pages (from-to)15-19
JournalInternational Journal of Radiation Biology
Volume93
Issue number1
DOIs
Publication statusPublished - 2 Jan 2017

Keywords

  • Biological dosimetry
  • dosimetry network
  • intercomparison
  • radiation emergency

Fingerprint Dive into the research topics of 'The RENEB operational basis: complement of established biodosimetric assays'. Together they form a unique fingerprint.

  • Cite this

    Wojcik, A., Oestreicher, U., Barrios, L., Vral, A., Terzoudi, G., Ainsbury, E., Rothkamm, K., Trompier, F., & Kulka, U. (2017). The RENEB operational basis: complement of established biodosimetric assays. International Journal of Radiation Biology, 93(1), 15-19. https://doi.org/10.1080/09553002.2016.1235296