The relationship between daily calcium intake and bone mineral density in men with prostate cancer

Jacques Planas, Juan Morote, Anna Orsola, Carlos Salvador, Enrique Trilla, Lluis Cecchini, Carles X. Raventós, Jacques P. Morin

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Abstract

OBJECTIVE: To analyse the relationship between daily calcium intake (DCI) and bone mineral density (BMD) in patients with prostate cancer, and to assess if DCI is a risk factor for osteoporosis in this group of patients. PATIENTS AND METHODS: DCI was assessed by a standard questionnaire answered by men with prostate cancer who had had bone densitometry. BMD was measured by dual-energy X-ray absorptiometry in the lumbar spine and different hip sites, in a cross-sectional study including 372 men with prostate cancer free of bone metastases, 71.5% (266) under androgen-deprivation therapy (ADT) and 28.5% (106) after radical prostatectomy (RP). Osteoporosis was defined according to the International Society for Clinical Densitometry official position (2005). RESULTS: A DCI of <1000 mg, the National Institute of Health recommendation, was detected in 93% of the men, (93.5% under ADT and 91.5% after RP). Osteoporosis was identified in 49.2% (183) of the patients, 54.9% (146) under ADT and 34.9% (37) after RP. The mean DCI was 609.7 mg in men with osteoporosis and 682.8 mg in those without (P < 0.001); in men under ADT the mean DCI remained significantly lower in those with osteoporosis (615.5 vs 700.4 mg, P < 0.001). A multivariate analysis showed that DCI was an independent risk factor for osteoporosis, together with patient age, ADT and its duration. CONCLUSIONS: DCI seems to be related to BMD; a low DCI was an independent risk factor for osteoporosis in men with prostate cancer. In the study population overall the DCI was inadequate. Urologists should recommend a DCI of >1000 mg in patients with prostate cancer, especially in those under ADT. © 2007 The Authors.
Original languageEnglish
Pages (from-to)812-815
JournalBJU International
Volume99
Issue number4
DOIs
Publication statusPublished - 1 Apr 2007

Keywords

  • Androgen deprivation therapy
  • Calcium intake
  • Osteoporosis
  • Prostate cancer

Fingerprint Dive into the research topics of 'The relationship between daily calcium intake and bone mineral density in men with prostate cancer'. Together they form a unique fingerprint.

  • Cite this