The real-life value of ST2 monitoring during heart failure decompensation: Impact on long-term readmission and mortality

Cinta Llibre; Elisabet Zamora; Àngel Caballero; Josep Lupón; Alba Ros; Nuria Benito; Marta De Antonio; Amparo Galán; Mar Domingo; Antoni Bayes-Genis

doi:10.3109/1354750X.2015.1130747

The real-life value of ST2 monitoring during heart failure decompensation: Impact on long-term readmission and mortality

Cinta Llibre, Elisabet Zamora, Àngel Caballero, Josep Lupón, Alba Ros, Nuria Benito, Marta De Antonio, Amparo Galán, Mar Domingo, Antoni Bayes-Genis

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

© 2016 Taylor & Francis. Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.

Original language	English
Pages (from-to)	225-232
Journal	Biomarkers
Volume	21
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2015.1130747
Publication status	Published - 2 Apr 2016

Keywords

Acute heart failure
biomarkers
outcomes
prognosis
ST2

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10.3109/1354750X.2015.1130747

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@article{5125654a38cd42e890d681aba4bb8d24,

title = "The real-life value of ST2 monitoring during heart failure decompensation: Impact on long-term readmission and mortality",

abstract = "{\textcopyright} 2016 Taylor & Francis. Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.",

keywords = "Acute heart failure, biomarkers, outcomes, prognosis, ST2",

author = "Cinta Llibre and Elisabet Zamora and {\`A}ngel Caballero and Josep Lup{\'o}n and Alba Ros and Nuria Benito and {De Antonio}, Marta and Amparo Gal{\'a}n and Mar Domingo and Antoni Bayes-Genis",

year = "2016",

month = apr,

day = "2",

doi = "10.3109/1354750X.2015.1130747",

language = "English",

volume = "21",

pages = "225--232",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Informa Healthcare",

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TY - JOUR

T1 - The real-life value of ST2 monitoring during heart failure decompensation: Impact on long-term readmission and mortality

AU - Llibre, Cinta

AU - Zamora, Elisabet

AU - Caballero, Àngel

AU - Lupón, Josep

AU - Ros, Alba

AU - Benito, Nuria

AU - De Antonio, Marta

AU - Galán, Amparo

AU - Domingo, Mar

AU - Bayes-Genis, Antoni

PY - 2016/4/2

Y1 - 2016/4/2

N2 - © 2016 Taylor & Francis. Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.

AB - © 2016 Taylor & Francis. Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.

KW - Acute heart failure

KW - biomarkers

KW - outcomes

KW - prognosis

KW - ST2

U2 - 10.3109/1354750X.2015.1130747

DO - 10.3109/1354750X.2015.1130747

M3 - Article

SN - 1354-750X

VL - 21

SP - 225

EP - 232

JO - Biomarkers

JF - Biomarkers

IS - 3

ER -

The real-life value of ST2 monitoring during heart failure decompensation: Impact on long-term readmission and mortality

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Keywords

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