The real-life value of ST2 monitoring during heart failure decompensation: Impact on long-term readmission and mortality

Cinta Llibre, Elisabet Zamora, Àngel Caballero, Josep Lupón, Alba Ros, Nuria Benito, Marta De Antonio, Amparo Galán, Mar Domingo, Antoni Bayes-Genis

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

© 2016 Taylor & Francis. Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.
Original languageEnglish
Pages (from-to)225-232
JournalBiomarkers
Volume21
Issue number3
DOIs
Publication statusPublished - 2 Apr 2016

Keywords

  • Acute heart failure
  • biomarkers
  • outcomes
  • prognosis
  • ST2

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