The PTPN22R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population

J. Castro-Marrero, E. Balada, M. Vilardell-Tarrés, J. Ordi-Ros

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

In this work, we proposed to determine the association of the PTPN22*R620W SNP with primary antiphospholipid syndrome (PAPS) in a case-control association study of Spanish Caucasian individuals. A total of 81 PAPS patients were compared with 81 blood-donor healthy control subjects. PTPN22 SNP (R620W) genotyping was performed by using a polymerase chain reaction-restricted fragment length polymorphism assay. No statistically significant differences were found between control subjects and PAPS patients for the PTPN22*R620W genotypes (P=0.214). No statistically significant differences were found according to either the presence or absence of antiphospholipid antibodies or the clinical manifestations associated to PAPS. Our results indicate that this functional PTPN22*R620W polymorphism is not associated to PAPS; it seems not to be a risk factor in our Spanish population. The effect of the PTPN22 SNP on clinical manifestations and presence of antiphospholipid antibodies in APS warrants further investigations. © 2011 Blackwell Publishing Ltd.
Original languageEnglish
Pages (from-to)529-531
JournalInternational Journal of Immunogenetics
Volume38
Issue number6
DOIs
Publication statusPublished - 1 Dec 2011

Fingerprint Dive into the research topics of 'The PTPN22R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population'. Together they form a unique fingerprint.

  • Cite this