The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

Jordi Ribera; Isabel Granada; Mireia Morgades; Susana Vives; Eulàlia Genescà; Celia González; Josep Nomdedeu; Lourdes Escoda; Pau Montesinos; Santiago Mercadal; Rosa Coll; José González-Campos; Eugenia Abella; Pere Barba; Arancha Bermúdez; Cristina Gil; Mar Tormo; María Pedreño; Daniel Martínez-Carballeira; Jesús María Hernández-Rivas; Alberto Orfao; Joaquín Martínez-López; Jordi Esteve; Pilar Bravo; Antoni Garcia-Guiñon; Guillermo Debén; José M. Moraleda; José A. Queizán; Xavier Ortín; María J. Moreno; Evarist Feliu; Francesc Solé; Josep M. Ribera

doi:10.1111/bjh.15887

The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

Jordi Ribera, Isabel Granada, Mireia Morgades, Susana Vives, Eulàlia Genescà, Celia González, Josep Nomdedeu, Lourdes Escoda, Pau Montesinos, Santiago Mercadal, Rosa Coll, José González-Campos, Eugenia Abella, Pere Barba, Arancha Bermúdez, Cristina Gil, Mar Tormo, María Pedreño, Daniel Martínez-Carballeira, Jesús María Hernández-RivasAlberto Orfao, Joaquín Martínez-López, Jordi Esteve, Pilar Bravo, Antoni Garcia-Guiñon, Guillermo Debén, José M. Moraleda, José A. Queizán, Xavier Ortín, María J. Moreno, Evarist Feliu, Francesc Solé, Josep M. Ribera

Department of Medicine

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5 Citations (Scopus)

Abstract

© 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

Original language	English
Pages (from-to)	263-268
Journal	British Journal of Haematology
Volume	186
DOIs	https://doi.org/10.1111/bjh.15887
Publication status	Published - 1 Jul 2019

Keywords

acute lymphoblastic leukaemia
adults
age
hypodiploidy
prognosis

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10.1111/bjh.15887

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Ribera, J., Granada, I., Morgades, M., Vives, S., Genescà, E., González, C., Nomdedeu, J., Escoda, L., Montesinos, P., Mercadal, S., Coll, R., González-Campos, J., Abella, E., Barba, P., Bermúdez, A., Gil, C., Tormo, M., Pedreño, M., Martínez-Carballeira, D., ... Ribera, J. M. (2019). The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients. British Journal of Haematology, 186, 263-268. https://doi.org/10.1111/bjh.15887

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title = "The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients",

abstract = "{\textcopyright} 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espa{\~n}ol de Tratamientos en Hematolog{\'i}a (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.",

keywords = "acute lymphoblastic leukaemia, adults, age, hypodiploidy, prognosis",

author = "Jordi Ribera and Isabel Granada and Mireia Morgades and Susana Vives and Eul{\`a}lia Genesc{\`a} and Celia Gonz{\'a}lez and Josep Nomdedeu and Lourdes Escoda and Pau Montesinos and Santiago Mercadal and Rosa Coll and Jos{\'e} Gonz{\'a}lez-Campos and Eugenia Abella and Pere Barba and Arancha Berm{\'u}dez and Cristina Gil and Mar Tormo and Mar{\'i}a Pedre{\~n}o and Daniel Mart{\'i}nez-Carballeira and Hern{\'a}ndez-Rivas, {Jes{\'u}s Mar{\'i}a} and Alberto Orfao and Joaqu{\'i}n Mart{\'i}nez-L{\'o}pez and Jordi Esteve and Pilar Bravo and Antoni Garcia-Gui{\~n}on and Guillermo Deb{\'e}n and Moraleda, {Jos{\'e} M.} and Queiz{\'a}n, {Jos{\'e} A.} and Xavier Ort{\'i}n and Moreno, {Mar{\'i}a J.} and Evarist Feliu and Francesc Sol{\'e} and Ribera, {Josep M.}",

year = "2019",

month = jul,

day = "1",

doi = "10.1111/bjh.15887",

language = "English",

volume = "186",

pages = "263--268",

journal = "British Journal of Haematology",

issn = "0007-1048",

}

Ribera, J, Granada, I, Morgades, M, Vives, S, Genescà, E, González, C, Nomdedeu, J, Escoda, L, Montesinos, P, Mercadal, S, Coll, R, González-Campos, J, Abella, E, Barba, P, Bermúdez, A, Gil, C, Tormo, M, Pedreño, M, Martínez-Carballeira, D, Hernández-Rivas, JM, Orfao, A, Martínez-López, J, Esteve, J, Bravo, P, Garcia-Guiñon, A, Debén, G, Moraleda, JM, Queizán, JA, Ortín, X, Moreno, MJ, Feliu, E, Solé, F & Ribera, JM 2019, 'The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients', British Journal of Haematology, vol. 186, pp. 263-268. https://doi.org/10.1111/bjh.15887

TY - JOUR

T1 - The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

AU - Ribera, Jordi

AU - Granada, Isabel

AU - Morgades, Mireia

AU - Vives, Susana

AU - Genescà, Eulàlia

AU - González, Celia

AU - Nomdedeu, Josep

AU - Escoda, Lourdes

AU - Montesinos, Pau

AU - Mercadal, Santiago

AU - Coll, Rosa

AU - González-Campos, José

AU - Abella, Eugenia

AU - Barba, Pere

AU - Bermúdez, Arancha

AU - Gil, Cristina

AU - Tormo, Mar

AU - Pedreño, María

AU - Martínez-Carballeira, Daniel

AU - Hernández-Rivas, Jesús María

AU - Orfao, Alberto

AU - Martínez-López, Joaquín

AU - Esteve, Jordi

AU - Bravo, Pilar

AU - Garcia-Guiñon, Antoni

AU - Debén, Guillermo

AU - Moraleda, José M.

AU - Queizán, José A.

AU - Ortín, Xavier

AU - Moreno, María J.

AU - Feliu, Evarist

AU - Solé, Francesc

AU - Ribera, Josep M.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - © 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

AB - © 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

KW - acute lymphoblastic leukaemia

KW - adults

KW - age

KW - hypodiploidy

KW - prognosis

U2 - 10.1111/bjh.15887

DO - 10.1111/bjh.15887

M3 - Article

C2 - 30916384

SN - 0007-1048

VL - 186

SP - 263

EP - 268

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -

The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

Abstract

Keywords

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