The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

Jordi Ribera, Isabel Granada, Mireia Morgades, Susana Vives, Eulàlia Genescà, Celia González, Josep Nomdedeu, Lourdes Escoda, Pau Montesinos, Santiago Mercadal, Rosa Coll, José González-Campos, Eugenia Abella, Pere Barba, Arancha Bermúdez, Cristina Gil, Mar Tormo, María Pedreño, Daniel Martínez-Carballeira, Jesús María Hernández-RivasAlberto Orfao, Joaquín Martínez-López, Jordi Esteve, Pilar Bravo, Antoni Garcia-Guiñon, Guillermo Debén, José M. Moraleda, José A. Queizán, Xavier Ortín, María J. Moreno, Evarist Feliu, Francesc Solé, Josep M. Ribera

Research output: Contribution to journalArticleResearch

2 Citations (Scopus)

Abstract

© 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
Original languageEnglish
Pages (from-to)263-268
JournalBritish Journal of Haematology
Volume186
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • acute lymphoblastic leukaemia
  • adults
  • age
  • hypodiploidy
  • prognosis

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