The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Matthias I. Gröschel, Conor J. Meehan, Ivan Barilar, Margo Diricks, Aitor Gonzaga, Matthias Steglich, Oscar Conchillo-Solé, Isabell Christin Scherer, Uwe Mamat, Christian F. Luz, Katrien De Bruyne, Christian Utpatel, Daniel Yero, Isidre Gibert, Xavier Daura, Stefanie Kampmeier, Nurdyana Abdul Rahman, Michael Kresken, Tjip S. van der Werf, Ifey AlioWolfgang R. Streit, Kai Zhou, Thomas Schwartz, John W.A. Rossen, Maha R. Farhat, Ulrich E. Schaible, Ulrich Nübel, Jan Rupp, Joerg Steinmann, Stefan Niemann, Thomas A. Kohl

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Abstract

Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.

Original languageAmerican English
Article number2044
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Dec 2020

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    Gröschel, M. I., Meehan, C. J., Barilar, I., Diricks, M., Gonzaga, A., Steglich, M., Conchillo-Solé, O., Scherer, I. C., Mamat, U., Luz, C. F., De Bruyne, K., Utpatel, C., Yero, D., Gibert, I., Daura, X., Kampmeier, S., Rahman, N. A., Kresken, M., van der Werf, T. S., ... Kohl, T. A. (2020). The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Nature Communications, 11(1), [2044]. https://doi.org/10.1038/s41467-020-15123-0