The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats

Muriel Darnaudéry; Marc Pallarès; Pier Vincenzo Piazza; Michel Le Moal; Willy Mayo

doi:https://doi.org/10.1016/S0006-8993(02)03166-9

The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats

Muriel Darnaudéry, Marc Pallarès, Pier Vincenzo Piazza, Michel Le Moal, Willy Mayo

Department of Psychobiology and Methodology of Health Sciences

Research output: Contribution to journal › Article › Research › peer-review

49 Citations (Scopus)

Abstract

The effects of an infusion of the neurosteroid pregnenolone sulfate into the medial septum on acetylcholine release in the hippocampus and on spatial memory were evaluated in two experiments. Results show that pregnenolone sulfate enhanced acetylcholine release by more than 50% of baseline and improved recognition memory of a familiar environment. Therefore, our results suggest that the septo-hippocampal pathway could be involved in the promnesic properties of this neurosteroid. © 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	237-242
Journal	Brain Research
Volume	951
DOIs	https://doi.org/10.1016/S0006-8993(02)03166-9
Publication status	Published - 4 Oct 2002

Keywords

Acetylcholine
Hippocampus
In vivo microdialysis
Neurosteroids
Septum
Spatial memory

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https://doi.org/10.1016/S0006-8993(02)03166-9

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title = "The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats",

abstract = "The effects of an infusion of the neurosteroid pregnenolone sulfate into the medial septum on acetylcholine release in the hippocampus and on spatial memory were evaluated in two experiments. Results show that pregnenolone sulfate enhanced acetylcholine release by more than 50% of baseline and improved recognition memory of a familiar environment. Therefore, our results suggest that the septo-hippocampal pathway could be involved in the promnesic properties of this neurosteroid. {\textcopyright} 2002 Elsevier Science B.V. All rights reserved.",

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author = "Muriel Darnaud{\'e}ry and Marc Pallar{\`e}s and Piazza, {Pier Vincenzo} and {Le Moal}, Michel and Willy Mayo",

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AU - Darnaudéry, Muriel

AU - Pallarès, Marc

AU - Piazza, Pier Vincenzo

AU - Le Moal, Michel

AU - Mayo, Willy

PY - 2002/10/4

Y1 - 2002/10/4

N2 - The effects of an infusion of the neurosteroid pregnenolone sulfate into the medial septum on acetylcholine release in the hippocampus and on spatial memory were evaluated in two experiments. Results show that pregnenolone sulfate enhanced acetylcholine release by more than 50% of baseline and improved recognition memory of a familiar environment. Therefore, our results suggest that the septo-hippocampal pathway could be involved in the promnesic properties of this neurosteroid. © 2002 Elsevier Science B.V. All rights reserved.

AB - The effects of an infusion of the neurosteroid pregnenolone sulfate into the medial septum on acetylcholine release in the hippocampus and on spatial memory were evaluated in two experiments. Results show that pregnenolone sulfate enhanced acetylcholine release by more than 50% of baseline and improved recognition memory of a familiar environment. Therefore, our results suggest that the septo-hippocampal pathway could be involved in the promnesic properties of this neurosteroid. © 2002 Elsevier Science B.V. All rights reserved.

KW - Acetylcholine

KW - Hippocampus

KW - In vivo microdialysis

KW - Neurosteroids

KW - Septum

KW - Spatial memory

U2 - https://doi.org/10.1016/S0006-8993(02)03166-9

DO - https://doi.org/10.1016/S0006-8993(02)03166-9

M3 - Article

VL - 951

SP - 237

EP - 242

ER -

The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats

Abstract

Keywords

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