The Neurobiology of Borderline Personality Disorder

Maria Mercedes Perez-Rodriguez; Andrea Bulbena-Cabré; Anahita Bassir Nia; Gillian Zipursky; Marianne Goodman; Antonia S. New

doi:10.1016/j.psc.2018.07.012

The Neurobiology of Borderline Personality Disorder

Maria Mercedes Perez-Rodriguez, Andrea Bulbena-Cabré, Anahita Bassir Nia, Gillian Zipursky, Marianne Goodman, Antonia S. New

Department of Psychiatry and Legal Medicine

Research output: Contribution to journal › Review article › Research › peer-review

44 Citations (Scopus)

Abstract

© 2018 Elsevier Inc. This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.

Original language	English
Pages (from-to)	633-650
Journal	Psychiatric Clinics of North America
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.psc.2018.07.012
Publication status	Published - 1 Dec 2018

Keywords

Alexithymia
Borderline personality disorder
Emotion dysregulation
Genetics
Impulsive aggression
Neuroimaging
Opioids
Oxytocin

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10.1016/j.psc.2018.07.012

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title = "The Neurobiology of Borderline Personality Disorder",

abstract = "{\textcopyright} 2018 Elsevier Inc. This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.",

keywords = "Alexithymia, Borderline personality disorder, Emotion dysregulation, Genetics, Impulsive aggression, Neuroimaging, Opioids, Oxytocin",

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T1 - The Neurobiology of Borderline Personality Disorder

AU - Perez-Rodriguez, Maria Mercedes

AU - Bulbena-Cabré, Andrea

AU - Bassir Nia, Anahita

AU - Zipursky, Gillian

AU - Goodman, Marianne

AU - New, Antonia S.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - © 2018 Elsevier Inc. This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.

AB - © 2018 Elsevier Inc. This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.

KW - Alexithymia

KW - Borderline personality disorder

KW - Emotion dysregulation

KW - Genetics

KW - Impulsive aggression

KW - Neuroimaging

KW - Opioids

KW - Oxytocin

U2 - 10.1016/j.psc.2018.07.012

DO - 10.1016/j.psc.2018.07.012

M3 - Review article

C2 - 30447729

SN - 0193-953X

VL - 41

SP - 633

EP - 650

JO - Psychiatric Clinics of North America

JF - Psychiatric Clinics of North America

IS - 4

ER -

The Neurobiology of Borderline Personality Disorder

Abstract

Keywords

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