TY - JOUR
T1 - The neural correlates of delay discounting in obesity and binge eating disorder
AU - Miranda-Olivos, Romina
AU - Steward, Trevor
AU - Martínez-Zalacaín, Ignacio
AU - Mestre-Bach, Gemma
AU - Juaneda-Seguí, Asier
AU - Jiménez-Murcia, Susana
AU - Fernández-Formoso, José A
AU - Vilarrasa, Nuria
AU - Veciana de Las Heras, Misericordia
AU - Custal, Nuria
AU - Virgili, Nuria
AU - Lopez-Urdiales, Rafael
AU - Menchón, José M
AU - Granero, Roser
AU - Soriano-Mas, Carles
AU - Fernandez-Aranda, Fernando
PY - 2021/4/26
Y1 - 2021/4/26
N2 - BACKGROUND AND AIMS: Increased delay discounting is associated with obesity and binge eating disorder (BED). Although BED and obesity frequently co-occur, the neural mechanisms underlying delay discounting in these conditions remain poorly understood.METHODS: Thirtyfive women with obesity, including 10 participants with obesity and BED and 31 controls completed a monetary delay discounting task during functional magnetic resonance imaging.RESULTS: We identified that increased discounting rates were associated with decreased activity in the left anterior insula in participants with obesity compared to controls when choosing immediate rewards over delayed rewards (PFWE < 0.05). An exploratory analysis comparing the BED subsample to the other groups did not detect significant differences.DISCUSSION AND CONCLUSIONS: Our findings suggest decreased activity in the anterior insula may underlie heightened delay discounting in individuals with obesity, contributing the probability of choosing immediate rewards over delayed rewards based on emotional states. Future studies including larger, more diverse samples are required to confirm these effects.
AB - BACKGROUND AND AIMS: Increased delay discounting is associated with obesity and binge eating disorder (BED). Although BED and obesity frequently co-occur, the neural mechanisms underlying delay discounting in these conditions remain poorly understood.METHODS: Thirtyfive women with obesity, including 10 participants with obesity and BED and 31 controls completed a monetary delay discounting task during functional magnetic resonance imaging.RESULTS: We identified that increased discounting rates were associated with decreased activity in the left anterior insula in participants with obesity compared to controls when choosing immediate rewards over delayed rewards (PFWE < 0.05). An exploratory analysis comparing the BED subsample to the other groups did not detect significant differences.DISCUSSION AND CONCLUSIONS: Our findings suggest decreased activity in the anterior insula may underlie heightened delay discounting in individuals with obesity, contributing the probability of choosing immediate rewards over delayed rewards based on emotional states. Future studies including larger, more diverse samples are required to confirm these effects.
U2 - 10.1556/2006.2021.00023
DO - 10.1556/2006.2021.00023
M3 - Article
C2 - 33950859
JO - Journal of Behavioral Addictions
JF - Journal of Behavioral Addictions
SN - 2062-5871
ER -