The MTOC/Golgi complex at the T-cell immunological synapse

Meritxell Roig-Martinez, Elena Saavedra-Lopez, Paola V. Casanova, George P. Cribaro, Carlos Barcia

Research output: Chapter in BookChapterResearchpeer-review

Abstract

T cells effectively explore the tissue in search for antigens. When activated, they dedicate a big amount of energy and resources to arrange a complex structure called immunological synapse (IS), containing a particular distribution of molecules defined as supramolecular activation clusters (SMACs), and become polarized toward the target cell in a manner that channels the information specifically. This arrangement is symmetrical and requires the polarization of the MTOC and the Golgi to be operational, especially for the proper delivery of lytic granules and the recycling of molecules three dimensionally segregated at the clustered interface. Alternatively, after the productive encounter, T cells need to rearrange again to newly navigate through the tissue, changing back to a motile state called immunological kinapse (IK). In this IK state, the MTOC and the Golgi apparatus are repositioned and recruited at the back of the T cell to facilitate motility, while the established symmetry of the elements of the SMACs is broken and distributed in a different pattern. Both states, IS and IK, are interchangeable and are mainly orchestrated by the MTOC/Golgi complex, being critical for an effective immune response.
Original languageEnglish
Title of host publicationResults and Problems in Cell Differentiation
Pages223-231
Number of pages9
Volume67
ISBN (Electronic)1861-0412
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameResults and Problems in Cell Differentiation
Volume67

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  • Cite this

    Roig-Martinez, M., Saavedra-Lopez, E., Casanova, P. V., Cribaro, G. P., & Barcia, C. (2019). The MTOC/Golgi complex at the T-cell immunological synapse. In Results and Problems in Cell Differentiation (Vol. 67, pp. 223-231). (Results and Problems in Cell Differentiation; Vol. 67). https://doi.org/10.1007/978-3-030-23173-6_9