T cells effectively explore the tissue in search for antigens. When activated, they dedicate a big amount of energy and resources to arrange a complex structure called immunological synapse (IS), containing a particular distribution of molecules defined as supramolecular activation clusters (SMACs), and become polarized toward the target cell in a manner that channels the information specifically. This arrangement is symmetrical and requires the polarization of the MTOC and the Golgi to be operational, especially for the proper delivery of lytic granules and the recycling of molecules three dimensionally segregated at the clustered interface. Alternatively, after the productive encounter, T cells need to rearrange again to newly navigate through the tissue, changing back to a motile state called immunological kinapse (IK). In this IK state, the MTOC and the Golgi apparatus are repositioned and recruited at the back of the T cell to facilitate motility, while the established symmetry of the elements of the SMACs is broken and distributed in a different pattern. Both states, IS and IK, are interchangeable and are mainly orchestrated by the MTOC/Golgi complex, being critical for an effective immune response.
|Title of host publication||Results and Problems in Cell Differentiation|
|Number of pages||9|
|Publication status||Published - 1 Jan 2019|
|Name||Results and Problems in Cell Differentiation|
Roig-Martinez, M., Saavedra-Lopez, E., Casanova, P. V., Cribaro, G. P., & Barcia, C. (2019). The MTOC/Golgi complex at the T-cell immunological synapse. In Results and Problems in Cell Differentiation (Vol. 67, pp. 223-231). (Results and Problems in Cell Differentiation; Vol. 67). https://doi.org/10.1007/978-3-030-23173-6_9