The MEGA Project: A Study of the Mechanisms Involved in the Genesis and Disease Course of Asthma. Asthma Cohort Creation and Long-Term Follow-Up

Xavier Muñoz, María José Álvarez-Puebla, Ebymar Arismendi, Lourdes Arochena, María del Pilar Ausín, Pilar Barranco, Irina Bobolea, Jose Antonio Cañas, Blanca Cardaba, Astrid Crespo, Victora del Pozo, Javier Domínguez-Ortega, María del Mar Fernandez-Nieto, Jordi Giner, Francisco Javier González-Barcala, Juan Alberto Luna, Joaquim Mullol, Iñigo Ojanguren, José María Olaguibel, César PicadoVicente Plaza, Santiago Quirce, David Ramos, Manuel Rial, Christian Romero-Mesones, Francisco Javier Salgado, María Esther San-José, Silvia Sánchez-Diez, Beatriz Sastre, Joaquin Sastre, Lorena Soto, Montserrat Torrejón, Marisa Urnadoz, Luis Valdes, Antonio Valero, María Jesús Cruz

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

© 2018 SEPAR The general aim of this study is to create a cohort of asthma patients with varying grades of severity in order to gain greater insight into the mechanisms underlying the genesis and course of this disease. The specific objectives focus on various studies, including imaging, lung function, inflammation, and bronchial hyperresponsiveness, to determine the relevant events that characterize the asthma population, the long-term parameters that can determine changes in the severity of patients, and the treatments that influence disease progression. The study will also seek to identify the causes of exacerbations and how this affects the course of the disease. Patients will be contacted via the outpatient clinics of the 8 participating institutions under the auspices of the Spanish Respiratory Diseases Networking System (CIBER). In the inclusion visit, a standardized clinical history will be obtained, a clinical examination, including blood pressure, body mass index, complete respiratory function tests, and FENO will be performed, and the Asthma Control Test (ACT), Morisky-Green test, Asthma Quality of Life Questionnaire (Mini AQLQ), the Sino-Nasal Outcome Test 22 (SNOT-22), and the Hospital Anxiety and Depression scale (HADS) will be administered. A specific electronic database has been designed for data collection. Exhaled breath condensate, urine and blood samples will also be collected. Non-specific bronchial hyperresponsiveness testing with methacholine will be performed and an induced sputum sample will be collected at the beginning of the study and every 24 months. A skin prick test for airborne allergens and a chest CT will be performed at the beginning of the study and repeated every 5 years.
Original languageEnglish
Pages (from-to)378-385
JournalArchivos de Bronconeumologia
Volume54
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Biomarkers
  • Bronchiectasis
  • Eosinophilic asthma
  • Epigenetics
  • Exacerbations
  • Fixed airflow obstruction
  • Neutrophilic asthma
  • Phenotype

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