The long term follow-up of early stage follicular lymphoma treated with radiotherapy, chemotherapy or combined modality treatment

Juan Manuel Sancho, Olga García, Santiago Mercadal, Helena Pomares, Rubén Fernández-Alvarez, Eva González-Barca, Gustavo Tapia, Esther González-García, Miriam Moreno, Eva Domingo-Domènech, Marc Sorigué, José Tomás Navarro, Cristina Motlló, Alberto Fernández-de-Sevilla, Evarist Feliu, Josep Maria Ribera

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13 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. Local (involved-field or recently involved-site) radiotherapy is the standard therapy in limited-stage follicular lymphoma (FL). We retrospectively analyzed the value of chemotherapy in 130 patients with limited-stage FL (46 treated with radiotherapy alone [RT group], 30 with radiotherapy plus chemotherapy [COMBINED group] and 43 with chemotherapy alone [CHEMO group], 11 were managed with observation). Ninety-six percent of patients responded (RT 98%, COMBINED 100%, CHEMO 91%, p = 0.179), and 37% (40/107) of patients in complete response relapsed (RT 42%, COMBINED 27%, CHEMO 41%, p = 0.371). Progression-free survival (PFS) and overall survival (OS) probabilities at 10 years were similar in RT, COMBINED and CHEMO patients (PFS 41%, 61% and 39% [p = 0.167], and OS 77%, 81% and 72% [ p = 0.821], respectively), while the COMBINED group showed a trend to better time-to-progression (TTP 43%, 72% and 47% [ p = 0.055]). On multivariate analysis, only a FLIPI score ≥2 showed a trend to influence PFS (HR 2.1 [95% confidence interval 0.9-4.6], p = 0.067), and OS (HR 2.4 [0.9-6.5], p = 0.084), while patients treated with radiotherapy plus chemotherapy (COMBINED group) showed a significantly better TTP compared with those receiving only RT (HR 0.3 [0.1-0.8], p = 0.024). In our study no benefit was observed in survival with the use of systemic therapy compared with local radiotherapy.
Original languageEnglish
Pages (from-to)853-858
JournalLeukemia Research
Volume39
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015

Keywords

  • Chemotherapy
  • Follicular lymphoma
  • Limited stage
  • Radiotherapy

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