The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P. J. Cardona, A. Cooper, M. Luquín, A. Ariza, F. Filipo, I. M. Orme, V. Ausina

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Abstract

The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.
Original languageEnglish
Pages (from-to)362-366
JournalScandinavian Journal of Immunology
Volume49
DOIs
Publication statusPublished - 28 Apr 1999

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