The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P. J. Cardona; A. Cooper; M. Luquín; A. Ariza; F. Filipo; I. M. Orme; V. Ausina

doi:https://doi.org/10.1046/j.1365-3083.1999.00522.x

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P. J. Cardona, A. Cooper, M. Luquín, A. Ariza, F. Filipo, I. M. Orme, V. Ausina

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Abstract

The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

Original language	English
Pages (from-to)	362-366
Journal	Scandinavian Journal of Immunology
Volume	49
DOIs	https://doi.org/10.1046/j.1365-3083.1999.00522.x
Publication status	Published - 28 Apr 1999

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title = "The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity",

abstract = "The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.",

author = "Cardona, {P. J.} and A. Cooper and M. Luqu{\'i}n and A. Ariza and F. Filipo and Orme, {I. M.} and V. Ausina",

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AU - Cardona, P. J.

AU - Cooper, A.

AU - Luquín, M.

AU - Ariza, A.

AU - Filipo, F.

AU - Orme, I. M.

AU - Ausina, V.

PY - 1999/4/28

Y1 - 1999/4/28

N2 - The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

AB - The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

U2 - https://doi.org/10.1046/j.1365-3083.1999.00522.x

DO - https://doi.org/10.1046/j.1365-3083.1999.00522.x

M3 - Article

SN - 0300-9475

VL - 49

SP - 362

EP - 366

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

ER -

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

Abstract

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