The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs

Pino Alonso, Clara López-Solà, Mónica Gratacós, Miquel Angel Fullana, Cinto Segalàs, Eva Real, Narcís Cardoner, Carles Soriano-Mas, Ben J. Harrison, Xavier Estivill, José M. Menchón

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16 Citations (Scopus)


Cognitive models emphasize the importance of dysfunctional beliefs as overimportance/need to control thoughts, perfectionism, intolerance of uncertainty, responsibility, and overestimation of threat in obsessive-compulsive disorder (OCD). Twin studies suggest that these beliefs are significantly heritable, but candidate genes associated with them have not been analyzed. We genotyped the Val158Met in the COMT gene and Val66Met variant in the BDNF gene in 141 OCD patients and analyzed their single and interactive effects on the obsessive beliefs questionnaire (OBQ-44). Variability in dysfunctional beliefs was not affected by the COMT or BDNF genotype in isolation, but we detected a significant COMT×. BDNF interaction effect on responsibility/overestimation of threat and overimportance/need to control thoughts scores. Subjects with the BDNF Met-present and the COMT Met-present genotype showed higher scores on responsibility/overestimation of threat. An interaction between dopaminergic and neurotrophic functional gene variants may influence dysfunctional beliefs hypothesized to contribute to the development of OCD. © 2013 Elsevier Ltd.
Original languageEnglish
Pages (from-to)321-327
JournalJournal of Anxiety Disorders
Issue number3
Publication statusPublished - 1 Jan 2013


  • BDNF
  • Cognition
  • COMT
  • Dysfunctional beliefs
  • OBQ-44
  • Obsessive-compulsive disorder


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