The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice

Medicine & Life Sciences

• delta Opioid Receptor 77%
• sulforafan 75%
• Opioid Receptors 67%
• Transcription Factors 45%
• 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide 30%
• Heme Oxygenase-1 30%
• Sciatic Nerve 27%
• Enkephalins 21%
• Type 2 Diabetes Mellitus 19%
• Hyperalgesia 18%
• Down-Regulation 18%
• rebemide 17%
• Hyperglycemia 15%
• Painful Neuropathy 13%
• Body Weight 12%
• Phosphorylation 11%
• quinone 10%
• Diabetic Neuropathies 10%
• NAD 8%
• Weight Gain 7%
• Oxidoreductases 7%
• Type 1 Diabetes Mellitus 7%
• Opioid Analgesics 7%
• Proteins 6%
• Glucose 5%

Agriculture & Biology

• analgesic effect 72%
• narcotics 69%
• sulforaphane 69%
• transcription factors 47%
• receptors 41%
• mice 35%
• heme oxygenase (biliverdin-producing) 32%
• noninsulin-dependent diabetes mellitus 28%
• nerve tissue 19%
• enkephalin 18%
• hyperglycemia 18%
• agonists 14%
• diabetic neuropathy 13%
• phosphorylation 13%
• insulin-dependent diabetes mellitus 11%
• peripheral nervous system diseases 10%
• NAD(P)H dehydrogenase (quinone) 10%
• body weight 9%
• weight gain 6%
• proteins 5%

Chemistry

• Sulforaphane 100%
• Antinociceptive 83%
• Antiallodynic 38%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 22%
• NAD(P)H 13%
• Weight Gain 12%
• Quinone 9%
• Protein 8%
• Dose 7%
• Glucose 7%
• Weight 5%