The impact of donor insemination on the risk of preeclampsia: A systematic review and meta-analysis

Mireia González-Comadran, Julio Urresta Avila, Alejandro Saavedra Tascón, Radhanari Jimenéz, Ivan Solà, Mario Brassesco, Ramón Carreras, Miguel Ángel Checa

Research output: Contribution to journalReview articleResearchpeer-review

29 Citations (Scopus)

Abstract

© 2014 Elsevier Ltd. All rights reserved. A systematic review and meta-analysis were performed to evaluate whether women who conceive with donor sperm have an increased risk of preeclampsia compared with those who use their partner's sperm. Studies that compared women who were impregnated by donor and partner sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates. Altogether, 10,898 women (2342 pregnancies by donor sperm versus 8556 by the partner's sperm) were included from seven observational studies. Conception using donor sperm was associated with an increased risk of preeclampsia (odds ratio [OR] 1.63, 95% CI 1.36-1.95) compared with using a partner's sperm. No difference was observed in the risk of gestational hypertension (OR 0.94, 95% CI 0.43-2.03). In conclusion, pregnancies achieved by donor sperm significantly increase the risk of preeclampsia, although the underlying mechanisms remain unclear. Additional studies are required to confirm these findings.
Original languageEnglish
Pages (from-to)160-166
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume182
DOIs
Publication statusPublished - 1 Nov 2014

Keywords

  • Donor sperm
  • Gestational hypertension
  • Infertility
  • Meta-analysis
  • Preeclampsia

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