The impact of additional margin coagulation with radiofrequency in liver resections with subcentimetric margin: can we improve the oncological results? A propensity score matching study

M. Villamonte, F. Burdío, E. Pueyo, A. Andaluz, X. Moll, E. Berjano, A. Radosevic, L. Grande, M. Pera, B. Ielpo, P. Sánchez-Velázquez

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Abstract

Background: Whereas the usefulness of radiofrequency (RF) energy as haemostatic method in liver surgery has become well established in the last decades, its intentional application on resection margins with the aim of reducing local recurrence is still debatable. Our goal was to compare the impact of an additional application of RF energy on the top of the resection surface, namely additional margin coagulation (AMC), on local recurrence (LR) when subjected to a subcentimeter margin. Methods: We retrospectively analyzed 185 patients out of a whole cohort of 283 patients who underwent radical hepatic resection with subcentimetric margin. After propensity score adjustment, patients were classified into two balanced groups according to whether RF was applied or not. Results: No significant differences were observed within groups in baseline characteristics after PSM adjustment. The LR rate was significantly higher in the Control than AMC Group: 12 patients (14.5%) vs. 4 patients (4.8%) (p = 0.039). The estimated 1, 3, and 5-year LR-free survival rates of patients in the Control and AMC Group were: 93.5%, 86.0%, 81.0% and 98.8%, 97.2%, 91.9%, respectively (p = 0.049). Univariate Cox analyses indicated that the use of the RF applicator was significantly associated with lower LR (HR = 0.29, 95% confidence interval 0.093–0.906, p = 0.033). The Control Group showed smaller coagulation widths than the AMC group (p < 0.001). Conclusions: An additional application of RF on the top of the resection surface is associated with less local hepatic recurrence than the use of conventional techniques.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Aged
  • Bile Duct Neoplasms/pathology
  • Carcinoma, Hepatocellular/pathology
  • Carcinoma/secondary
  • Cholangiocarcinoma/pathology
  • Colorectal Neoplasms/pathology
  • Disease-Free Survival
  • Female
  • Hepatectomy/methods
  • Humans
  • Liver Neoplasms/pathology
  • Male
  • Margins of Excision
  • Metastasectomy
  • Middle Aged
  • Neoplasm Recurrence, Local/epidemiology
  • Postoperative Complications/epidemiology
  • Propensity Score
  • Radiofrequency Ablation/methods
  • Retrospective Studies
  • Treatment Outcome
  • Tumor Burden

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