The genotoxic effect of β-propiolactone on mammalian oocytes

J. Santaló, A. M. Estop, J. Egozcue

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    Abstract

    β-Propiolactone (βPL) has been tested on preimplantation mouse embryos for possible genotoxic effects. Tests were performed at different stages of meiosis (late prophase I, diakinesis/metaphase I, anaphase I, telophase I/prophase II and metaphase II) by injecting females at various times after the induction of superovulation. Male and female derived chromosome complements from first-cleavage embryos were analysed before syngamy for cytogenetic abnormalities. A higher proportion of diploid oocytes, produced by the non-extrusion of the first or second polar body, was found after fertilization when the compound was administered immediately before metaphase I or II. No obvious effect was detected at any other time of βPL exposure. Based on these results, several possible modes of action for βPL are postulated. © 1987.
    Original languageEnglish
    Pages (from-to)407-416
    JournalMutation Research/Genetic Toxicology
    Volume189
    Issue number4
    DOIs
    Publication statusPublished - 1 Jan 1987

    Keywords

    • (Mammalian oocytes)
    • (Mouse embryos)
    • Meiosis, different stages
    • β-Propiolactone

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