The generation of antimicrobial peptide activity: A trade-off between charge and aggregation?

Marc Torrent, Javier Valle, M. Victòria Nogués, Ester Boix, David Andreu

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Action stations: Antimicrobial peptides (AMPs) can be derived from amyloid-prone regions by introduction of cationic residues at privileged positions (see picture). The design and testing of 24 de novo amyloid-derived AMPs are described, and the likelihood of evolution of amyloid-prone protein regions, devoid of antimicrobial activity, into potent antimicrobial domains is addressed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)10686-10689
JournalAngewandte Chemie - International Edition
Volume50
DOIs
Publication statusPublished - 4 Nov 2011

Keywords

  • aggregation
  • amyloids
  • antimicrobial agents
  • molecular evolution
  • peptides

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