The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

L. Sánchez-García, N. Serna, M. Mattanovich, P. Cazzanelli, A. Sánchez-Chardi, O. Conchillo-Solé, F. Cortés, X. Daura, U. Unzueta, R. Mangues, A. Villaverde, E. Vázquez

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

This journal is © 2017 The Royal Society of Chemistry. We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.
Original languageEnglish
Pages (from-to)4565-4568
JournalChemical Communications
Volume53
Issue number33
DOIs
Publication statusPublished - 1 Jan 2017

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