The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

L. Sánchez-García; N. Serna; M. Mattanovich; P. Cazzanelli; A. Sánchez-Chardi; O. Conchillo-Solé; F. Cortés; X. Daura; U. Unzueta; R. Mangues; A. Villaverde; E. Vázquez

doi:10.1039/c6cc09900a

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

L. Sánchez-García, N. Serna, M. Mattanovich, P. Cazzanelli, A. Sánchez-Chardi, O. Conchillo-Solé, F. Cortés, X. Daura, U. Unzueta, R. Mangues, A. Villaverde, E. Vázquez

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Abstract

This journal is © 2017 The Royal Society of Chemistry. We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

Original language	English
Pages (from-to)	4565-4568
Journal	Chemical Communications
Volume	53
Issue number	33
DOIs	https://doi.org/10.1039/c6cc09900a
Publication status	Published - 1 Jan 2017

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abstract = "This journal is {\textcopyright} 2017 The Royal Society of Chemistry. We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.",

author = "L. S{\'a}nchez-Garc{\'i}a and N. Serna and M. Mattanovich and P. Cazzanelli and A. S{\'a}nchez-Chardi and O. Conchillo-Sol{\'e} and F. Cort{\'e}s and X. Daura and U. Unzueta and R. Mangues and A. Villaverde and E. V{\'a}zquez",

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AU - Sánchez-García, L.

AU - Serna, N.

AU - Mattanovich, M.

AU - Cazzanelli, P.

AU - Sánchez-Chardi, A.

AU - Conchillo-Solé, O.

AU - Cortés, F.

AU - Daura, X.

AU - Unzueta, U.

AU - Mangues, R.

AU - Villaverde, A.

AU - Vázquez, E.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - This journal is © 2017 The Royal Society of Chemistry. We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

AB - This journal is © 2017 The Royal Society of Chemistry. We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

U2 - 10.1039/c6cc09900a

DO - 10.1039/c6cc09900a

M3 - Article

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VL - 53

SP - 4565

EP - 4568

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

Abstract

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