Abstract
This journal is © 2017 The Royal Society of Chemistry. We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.
Original language | English |
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Pages (from-to) | 4565-4568 |
Journal | Chemical Communications |
Volume | 53 |
Issue number | 33 |
DOIs | |
Publication status | Published - 1 Jan 2017 |