The evaluation of heterosexual transmission of the human immunodeficiency virus by nucleic acid amplification technics

V. Soriano, I. Hewlett, J. Tor, C. de Amo, I. Lázaro, R. Muga, R. Clotet, M. Ribas-Mundó, M. Foz

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1 Citation (Scopus)

Abstract

Heterosexual couples of individuals infected by HIV represent a group of high risk of virus infection. We have investigated the presence of fragments of the HIV genome with a new nucleic acid amplification technique (PCR or polymerase chain reaction) in lymphocytes from 33 seronegative couples with anti-HIV antibodies, most of which were heroin addicts. 12 of the 33 couples (36%) had positive PCR for a gag HIV amplimer in the absence of antibodies. 4 of them (12%) also showed reactivity for sequences from an env amplimer. A control group of 7 patients with AIDS and 4 seropositive couples showed reactivity to gag and env in all. It is concluded that silent HIV infection may frequently develop in heterosexual couples of infected individuals.
Original languageEnglish
Pages (from-to)535-537
JournalMedicina clínica
Volume95
Issue number14
Publication statusPublished - 1 Jan 1990

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