The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases

Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Amelia Ruffatti, Angela Tincani, Elmina Lefkou, Ma Tiziana Bertero, Emmanuel Coloma-Bazan, Sara de Carolis, Gerard Espinosa, Patrizia Rovere-Querini, Anna Kuzenko, Enrique E. Valverde, Angel Robles, Ricard Cervera, Valentina Canti, Micaela Fredi, Antonio Gil-Aguado, Krista Lundelin, Elisa Llurba, Taisiya MelnychukCecilia Nalli, Elisa Picardo, Erika Silvestro, Teresa del Ross, Inmaculada Farran-Codina

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Abstract

© 2015 Elsevier B.V. Aim: To analyse the clinical features, laboratory data, foetal-maternal outcomes, and follow-up in a cohort of 247 women with obstetric antiphospholipid syndrome (OAPS). Methods: The European Registry on APS became a Registry within the framework of the European Forum on Antiphospholipid Antibody projects and placed on a website in June 2010. Cases with obstetric complaints related to aPL who tested positive for aPL prospectively and retrospectively were included. The three-year survey results are reported. Results: 338 women with 1253 pregnancy episodes were included; 915 were historical and 338 were latest episodes. All these women tested positive for aPL. 247 of the 338 fulfilled the Sydney criteria. According to the laboratory categories, 84/247 were in category I, 42 in IIa, 66 in IIb and 55 in IIc. Obstetric complications other than foetal losses, appeared in 129 cases (52.2%). 192 (77.7%) had a live birth and 55 (22.3%) did not. The latter group of only 38 cases (69%) received adequate treatment and 17 (31%) did not. 177/247 (72%) women were put on heparin plus LDA. Thrombosis appeared in two during pregnancy and in 14 during the puerperium. 7 (3%) women evolved to complete SLE. Conclusions: OAPS shows differential characteristics than classical APS. All laboratory test categories are needed to avoid false-negative diagnoses. In some cases, complement levels could act as a serological marker. OAPS has very good foetal-maternal outcomes when treated. Thrombosis and progression to SLE in mothers with OAPS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms.
Original languageEnglish
Pages (from-to)387-395
JournalAutoimmunity Reviews
Volume14
Issue number5
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • Antiphospholipid antibody
  • Laboratory categories
  • Obstetric antiphospholipid syndrome
  • Obstetric morbidity
  • Registry
  • Treatment

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    Alijotas-Reig, J., Ferrer-Oliveras, R., Ruffatti, A., Tincani, A., Lefkou, E., Bertero, M. T., Coloma-Bazan, E., de Carolis, S., Espinosa, G., Rovere-Querini, P., Kuzenko, A., Valverde, E. E., Robles, A., Cervera, R., Canti, V., Fredi, M., Gil-Aguado, A., Lundelin, K., Llurba, E., ... Farran-Codina, I. (2015). The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases. Autoimmunity Reviews, 14(5), 387-395. https://doi.org/10.1016/j.autrev.2014.12.010