The epidermal growth factor receptor pathway: A model for targeted therapy

Maurizio Scaltriti, José Baselga

Research output: Contribution to journalReview articleResearchpeer-review

604 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as a target for cancer therapy, and after 2 decades of intensive research, there are several anti-EGFR agents available in the clinic. Recent advances in our understanding in the mechanisms of receptor activation and function, discovery of primary and secondary EGFR somatic mutations, as well as a new generation of anti-EGFR agents provide new leads on the clinical targeting of this receptor and may serve as a model for strategies aimed at targeting other receptors. © 2006 American Association for Cancer Research.
Original languageEnglish
Pages (from-to)5268-5272
JournalClinical Cancer Research
Volume12
Issue number18
DOIs
Publication statusPublished - 15 Sep 2006

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