TY - JOUR
T1 - The endometria of patients with endometriosis show higher expression of class I human leukocyte antigen than the endometria of healthy women
AU - Del Mar Vernet-Tomás, María
AU - Pérez-Ares, Carlos T.
AU - Verdú, Núria
AU - Molinero, José Luis
AU - Fernández-Figueras, María Teresa
AU - Carreras, Ramon
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Objective: To compare the expression of class I human leukocyte antigen (HLA I) in endometrial samples from patients with and without endometriosis. Design: Cross-sectional study. Setting: Acute-care teaching hospital in Barcelona, Spain. Patient(s): The endometriosis group included 32 patients for whom the only diagnosis during an operation was endometriosis. The control group included 20 women who underwent a laparoscopy and in whom no evidence of endometriosis or any other genital disease was seen. Intervention(s): Samples of endometrium were obtained by curettage and immediately frozen. A pan-HLA I mouse antihuman IgG2a monoclonal antibody was used for immunohistochemical study. Main Outcome Measure(s): Frequency of positive glandular and stromal cells was evaluated in each section. Result(s): A significantly higher expression of HLA I in the endometriosis group than in controls, both in the glandular cells (median 100% vs. 80%) and in the stromal cells (median 60% vs. 20%), was observed. Conclusion(s): Patients with endometriosis had a significantly higher expression of HLA I molecules in endometrial cells than did the controls. This could be a possible explanation for their higher resistance to natural killer cytolysis. ©2006 by American Society for Reproductive Medicine.
AB - Objective: To compare the expression of class I human leukocyte antigen (HLA I) in endometrial samples from patients with and without endometriosis. Design: Cross-sectional study. Setting: Acute-care teaching hospital in Barcelona, Spain. Patient(s): The endometriosis group included 32 patients for whom the only diagnosis during an operation was endometriosis. The control group included 20 women who underwent a laparoscopy and in whom no evidence of endometriosis or any other genital disease was seen. Intervention(s): Samples of endometrium were obtained by curettage and immediately frozen. A pan-HLA I mouse antihuman IgG2a monoclonal antibody was used for immunohistochemical study. Main Outcome Measure(s): Frequency of positive glandular and stromal cells was evaluated in each section. Result(s): A significantly higher expression of HLA I in the endometriosis group than in controls, both in the glandular cells (median 100% vs. 80%) and in the stromal cells (median 60% vs. 20%), was observed. Conclusion(s): Patients with endometriosis had a significantly higher expression of HLA I molecules in endometrial cells than did the controls. This could be a possible explanation for their higher resistance to natural killer cytolysis. ©2006 by American Society for Reproductive Medicine.
KW - Class I HLA
KW - Endometriosis
KW - Immunohistochemistry
KW - Natural killer cells
U2 - 10.1016/j.fertnstert.2005.06.057
DO - 10.1016/j.fertnstert.2005.06.057
M3 - Article
SN - 0015-0282
VL - 85
SP - 78
EP - 83
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -
