The endometria of patients with endometriosis show higher expression of class I human leukocyte antigen than the endometria of healthy women

María Del Mar Vernet-Tomás, Carlos T. Pérez-Ares, Núria Verdú, José Luis Molinero, María Teresa Fernández-Figueras, Ramon Carreras

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27 Citations (Scopus)

Abstract

Objective: To compare the expression of class I human leukocyte antigen (HLA I) in endometrial samples from patients with and without endometriosis. Design: Cross-sectional study. Setting: Acute-care teaching hospital in Barcelona, Spain. Patient(s): The endometriosis group included 32 patients for whom the only diagnosis during an operation was endometriosis. The control group included 20 women who underwent a laparoscopy and in whom no evidence of endometriosis or any other genital disease was seen. Intervention(s): Samples of endometrium were obtained by curettage and immediately frozen. A pan-HLA I mouse antihuman IgG2a monoclonal antibody was used for immunohistochemical study. Main Outcome Measure(s): Frequency of positive glandular and stromal cells was evaluated in each section. Result(s): A significantly higher expression of HLA I in the endometriosis group than in controls, both in the glandular cells (median 100% vs. 80%) and in the stromal cells (median 60% vs. 20%), was observed. Conclusion(s): Patients with endometriosis had a significantly higher expression of HLA I molecules in endometrial cells than did the controls. This could be a possible explanation for their higher resistance to natural killer cytolysis. ©2006 by American Society for Reproductive Medicine.
Original languageEnglish
Pages (from-to)78-83
JournalFertility and Sterility
Volume85
Issue number1
DOIs
Publication statusPublished - 1 Jan 2006

Keywords

  • Class I HLA
  • Endometriosis
  • Immunohistochemistry
  • Natural killer cells

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