The EMT signaling pathways in endometrial carcinoma

Eva Colas, Nuria Pedrola, Laura Devis, Tugçe Ertekin, Irene Campoy, Elena Martínez, Marta Llauradó, Marina Rigau, Mireia Olivan, Marta Garcia, Silvia Cabrera, Antonio Gil-Moreno, Jordi Xercavins, Josep Castellvi, Angel Garcia, S. Santiago Ramon Y Cajal, Gema Moreno-Bueno, Xavier Dolcet, Francesc Alameda, Jose PalaciosJaime Prat, Andreas Doll, Xavier Matias-Guiu, Miguel Abal, Jaume Reventos

Research output: Contribution to journalReview articleResearchpeer-review

70 Citations (Scopus)

Abstract

Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGFβ, ETV5 and microRNAs are deeply related to the EMT process in EC. © Federación de Sociedades Españolas de Oncología (FESEO) 2012.
Original languageEnglish
Pages (from-to)715-720
JournalClinical and Translational Oncology
Volume14
Issue number10
DOIs
Publication statusPublished - 1 Oct 2012

Keywords

  • EMT
  • Endometrial cancer
  • Invasion

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