The efficiency of purifying selection in Mammals vs. Drosophila for metabolic genes

N. Petit, A. Barbadilla

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The nearly neutral theory of molecular evolution states that the efficiency of natural selection depends on the effective population size. By using a wide range of multispecies data on nucleotide polymorphism, we have tried to ascertain whether there are any differences in the level of selective constraints of metabolic process genes between Mammals and Drosophila species. The results are consistent with a higher selective constraint in Drosophila than in Mammals, according to the expected under the nearly neutral model: purifying selection seems to be more efficient in species with a larger effective population size. © 2009 European Society For Evolutionary Biology.
Original languageEnglish
Pages (from-to)2118-2124
JournalJournal of Evolutionary Biology
Volume22
Issue number10
DOIs
Publication statusPublished - 1 Oct 2009

Keywords

  • Effective population size
  • Evolution
  • Genetic drift
  • Nearly neutral theory
  • Polymorphism

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