The effect of perioperative administration of probiotics on colorectal cancer surgery outcomes

Louise Pitsillides, Gianluca Pellino, Paris Tekkis, Christos Kontovounisios*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

7 Citations (Scopus)


1 Abstract: The perioperative care of colorectal cancer (CRC) patients includes antibiotics. Although antibiotics do provide a certain protection against infections, they do not eliminate them completely, and they do carry risks of microbial resistance and disruption of the microbiome. Probiotics can maintain the microbiome’s balance postoperatively by maintaining intestinal mucosal integrity and reducing bacterial translocation (BT). This review aims to assess the role of probiotics in the perioperative management of CRC patients. The outcomes were categorised into: postoperative infectious and non-infectious complications, BT rate analysis, and intestinal permeability assessment. Fifteen randomised controlled trials (RCTs) were included. There was a trend towards lower rates of postoperative infectious and non-infectious complications with probiotics versus placebo. Probiotics reduced BT, maintained intestinal mucosal permeability, and provided a better balance of beneficial to pathogenic microorganisms. Heterogeneity among RCTs was high. Factors that influence the effect of probiotics include the species used, using a combination vs. single species, the duration of administration, and the location of the bowel resection. Although this review provided evidence for how probiotics possibly operate and reported notable evidence that probiotics can lower rates of infections, heterogeneity was observed. In order to corroborate the findings, future RCTs should keep the aforementioned factors constant.

Original languageEnglish
Article number1451
Number of pages12
Issue number5
Publication statusPublished - May 2021


  • Colonic resection
  • Colorectal cancer
  • Colorectal surgery
  • Perioperative care
  • Probiotics


Dive into the research topics of 'The effect of perioperative administration of probiotics on colorectal cancer surgery outcomes'. Together they form a unique fingerprint.

Cite this