The effect of cadmium exposure and stress on plasma cortisol, metallothionein levels and oxidative status in rainbow trout (Oncorhynchus mykiss) liver

L. Tort, B. Kargacin, P. Torres, M. Giralt, J. Hidalgo

    Research output: Contribution to journalArticleResearchpeer-review

    59 Citations (Scopus)

    Abstract

    Selected variables related to the stress response in mammals, such as cortisol, metallothionein (MT), glutathione (GSH) and lipid peroxidation measured as thiobarbituric acid-reactants (TBARs) were evaluated in rainbow trout in order to establish whether chemical stress by cadmium exposure or physical stress by handling cause a significant response and comparable effects between stressors. The results obtained show about three times higher levels of liver MT in fish exposed to cadmium as compared to controls and twice as high after stress, whereas plasma cortisol levels increased significantly both after stress and cadmium exposure. This indicates that both MT and cortisol were sensitive indexes to stress in this species. In contrast, liver cytosolic GSH was affected only by cadmium treatment and liver TBARs remained unaffected.
    Original languageEnglish
    Pages (from-to)29-34
    JournalComparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
    Volume114
    DOIs
    Publication statusPublished - 1 Jan 1996

    Keywords

    • Zn
    • cadmium
    • cortisol
    • glutathione
    • lipid peroxidation
    • metallothionein
    • rainbow trout
    • stress

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