The effect of atorvastatin treatment on HIV-1-infected patients interrupting antiretroviral therapy

Eugènia Negredo, Bonaventura Clotet, Jordi Puig, Núria Pérez-Álvarez, Lidia Ruiz, Joan Romeu, José Moltó, Celestino Rey-Joly, Julià Blanco

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26 Citations (Scopus)

Abstract

We conducted a pilot study to assess the effect of atorvastatin on HIV replication. Patients with stable HAART-controlled infection interrupted therapy and were randomly assigned to a control group or to start atorvastatin 40 or 80 mg/day. Statin groups showed lower serum cholesterol but similar viral loads and CD4 T-cell counts to the control group at weeks 4 and 12. Paradoxically, baseline serum cholesterol, but not atorvastatin, influenced viral rebound at week 4. © 2006 Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)619-621
JournalAIDS
Volume20
Issue number4
DOIs
Publication statusPublished - 1 Feb 2006

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