TY - JOUR
T1 - The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms
AU - Benito, Natividad
AU - Mur, Isabel
AU - Ribera, Alba
AU - Soriano, Alex
AU - Rodríguez-Pardo, Dolors
AU - Sorlí, Luisa
AU - Cobo, Javier
AU - Fernández-Sampedro, Marta
AU - Del Toro, María Dolores
AU - Guío, Laura
AU - Praena, Julia
AU - Bahamonde, Alberto
AU - Riera, Melchor
AU - Esteban, Jaime
AU - Baraia-Etxaburu, Josu Mirena
AU - Martínez-Alvarez, Jesús
AU - Jover-Sáenz, Alfredo
AU - Dueñas, Carlos
AU - Ramos, Antonio
AU - Sobrino, Beatriz
AU - Euba, Gorane
AU - Morata, Laura
AU - Pigrau, Carles
AU - Horcajada, Juan P
AU - Coll, Pere
AU - Crusi, Xavier
AU - Ariza, Javier
PY - 2019/5/13
Y1 - 2019/5/13
N2 - The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
AB - The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
UR - https://www.mdpi.com/2077-0383/8/5/673
U2 - https://doi.org/10.3390/jcm8050673
DO - https://doi.org/10.3390/jcm8050673
M3 - Artículo
C2 - 31086080
VL - 8
IS - 5
ER -