The current role of MRI in differentiating multiple sclerosis from its imaging mimics

Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C. DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou, Jacqueline Palace

    Research output: Contribution to journalReview articleResearchpeer-review

    57 Citations (Scopus)

    Abstract

    © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. MRI red flags proposed over a decade ago by the European Magnetic Resonance Network in MS (MAGNIMS) have guided clinicians in the diagnosis of multiple sclerosis (MS). However, the past 10 years have seen increased recognition that vascular disease can coexist and possibly interact with MS, improvements in the reliability of ways to differentiate MS from novel antibody-mediated CNS disorders (such as anti-aquaporin-4 antibody and myelin-oligodendrocyte glycoprotein antibody-associated diseases) and advances in MRI techniques. In this Review, MAGNIMS updates the imaging features that differentiate the most common mimics of MS, particularly age-related cerebrovascular disease and neuromyelitis optica, from MS itself. We also provide a pragmatic summary of the clinically useful MRI features that distinguish MS from its mimics and discuss the future of nonconventional techniques that have identified promising disease-specific features.
    Original languageEnglish
    Pages (from-to)199-213
    JournalNature Reviews Neurology
    Volume14
    Issue number4
    DOIs
    Publication statusPublished - 1 Apr 2018

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  • Cite this

    Geraldes, R., Ciccarelli, O., Barkhof, F., De Stefano, N., Enzinger, C., Filippi, M., Hofer, M., Paul, F., Preziosa, P., Rovira, A., DeLuca, G. C., Kappos, L., Yousry, T., Fazekas, F., Frederiksen, J., Gasperini, C., Sastre-Garriga, J., Evangelou, N., & Palace, J. (2018). The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nature Reviews Neurology, 14(4), 199-213. https://doi.org/10.1038/nrneurol.2018.14