The CSIC reaction on substrates derived from aldehydes

José L. Marco, Simon T. Ingate, Carlos Jaime, Ivan Beá

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)


The Carbanion-mediated Sulfonate (Sulfonamide) Intramolecular Cyclization reaction (CSIC reaction) on conveniently functionalized cyanoalkylsulfonates and cyanoalkylsulfonamides derived from aldehydes is possible and gives the new heterocyclic ring systems 5-alkyl-4-amino-5H-1,2- oxathiole 2,2-dioxide and 3-alkyl-5H-4-amino-5-cyano-5H-2,3- dihydroisothiazole 1,1-dioxide in good yield. (C) 2000 Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)2523-2531
Issue number16
Publication statusPublished - 14 Apr 2000


  • Cyanoalkylsulfonamides
  • Cyanoalkylsulfonates
  • Non-nucleophilic bases

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