The clearance of lipoprotein X in vitro, and effect of phospholipase a on serum lipoprotein X

J. Rubies-Prat, M. R. Ras, J. C. Frison, S. Masdeu, R. Bacardi

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

The in vitro effect of post-heparin and post-heparin plus post-protamine normal serum on serum lipoprotein X (LP-X) is described. Serum LP-X is cleared after incubation with post-heparin normal serum, and serum LP-X remain unmodified when it is incubated with post-heparin plus post-protamine normal serum. The action of phospholipase A from snake venom on serum LP-X is also studied. A very small quantity of phospholipase is necessary to degrade LP-X and to transform lecithin into lysolecithin. It is concluded that phospholipase seems to be the enzyme that most likely induces the LP-X chnges after heparin administration. © 1977.
Original languageEnglish
Pages (from-to)117-121
JournalClinica Chimica Acta
Volume75
Issue number1
DOIs
Publication statusPublished - 15 Feb 1977

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