The changing pattern of non-small cell lung cancer between the 90th and 2000th decades

Jesus Montesinos, Marisa Bare, Elsa Dalmau, Eugeni Saigi, Pablo Villace, Miquel Nogue, Miquel Angel Segui, Anna Arnau, Xavier Bonfill

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Background: In Europe, approximately 381,500 patients are diagnosed with non-small cell lung cancer (NSCLC) every year. The aim of this study is to analyse the changes in diagnosis, treatment and evolution during the last two decades, using data from a hospital registry. Material and Methods: Patients diagnosed with NSCLC at the Corporació Sanitària Parc Taulí-Sabadell (Catalonia, Spain) during the periods 1990-1997 (n=748) and 2003-2005 (n=311) were included. The hospital tumour registry was used for prospective data collection. Results: Our series shows a significant increase in women diagnosed with NSCLC (6% vs 10.3%; p 0.01) in the latter period; the incidence of adenocarcinomas increased by 20% (31% vs 51.1%), whereas that of squamous cell carcinomas fell (51.3% vs 32.5%; p<0.001). The proportion of patients receiving active treatment also increased significantly, from 56.6% to 76.5% (p<0.001). Disease stage at diagnosis and the number of patients treated by radical surgical resection remained unchanged. Among the favourable independent prognostic factors for survival were: gender (women), age less than 70 years old, Karnofsky index ≥70%, early stage at diagnosis, treatment with chemotherapy, and being diagnosed in the latter period 2003-2005 (HR 0.67). Over this 10-year period, absolute gain in mean survival in our series was 115 days. Conclusions: The absolute gain in mean survival in NSCLC patients in the period studied was 3.8 months, with a 6.75% increase in 5-year survival. Hospital registry data may help the correct assessment of epidemiological changes and the real effectiveness of treatments, which are sometimes overestimated in clinical trials. © Montesinos et al.
Original languageEnglish
Pages (from-to)24-30
JournalOpen Respiratory Medicine Journal
Volume5
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • Carcinoma
  • Mortality
  • Multivariate analysis
  • Non-small cell lung
  • Registries

Fingerprint Dive into the research topics of 'The changing pattern of non-small cell lung cancer between the 90<sup>th</sup> and 2000<sup>th</sup> decades'. Together they form a unique fingerprint.

Cite this