The carbapenemase-producing Klebsiella pneumoniae population is distinct and more clonal than the carbapenem-susceptible population

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17 Citations (Scopus)

Abstract

We studied in parallel the population structure of 90 carbapenemase-producing and 88 carbapenemase-susceptible Klebsiella pneumoniae isolates collected in 20 Spanish hospitals, in the context of the EuSCAPE project. Fourteen and 50 multilocus sequence types (MLSTs) were detected among the carbapenemase-producing and carbapenem-susceptible isolates, respectively. ST11 and ST15 clones were more frequent in the carbapenemase-producing group than in the carbapenemase-susceptible group (P < 0.0001). Among the members of the carbapenem-suceptible group, the cefotaxime-resistant population showed population parameters that differed between the populations of the wild-type strains and the carbapenemase producers.

Original languageEnglish
Article numbere02520-16
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number4
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Carbapenem resistance
  • Carbapenemases
  • Klebsiella pneumoniae
  • MLST
  • Population structure

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