Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer. © 2013 Elsevier Ireland Ltd.
|Publication status||Published - 26 Aug 2013|
- AMPA receptors
- Cognitive enhancer
- Memory facilitation
- Olfactory discrimination
- Prefrontal cortex
Yefimenko, N., Portero-Tresserra, M., Martí-Nicolovius, M., Guillazo-Blanch, G., & Vale-Martínez, A. (2013). The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association. Neuroscience Letters, 548, 105-109. https://doi.org/10.1016/j.neulet.2013.05.032