The ageing lens and cataract: A model of normal and pathological ageing

R. Michael, A. J. Bron

    Research output: Contribution to journalReview articleResearchpeer-review

    237 Citations (Scopus)

    Abstract

    Cataract is a visible opacity in the lens substance, which, when located on the visual axis, leads to visual loss. Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences. With ageing, lens proteins undergo non-enzymatic, post-translational modification and the accumulation of fluorescent chromophores, increasing susceptibility to oxidation and cross-linking and increased light-scatter. Because the human lens grows throughout life, the lens core is exposed for a longer period to such influences and the risk of oxidative damage increases in the fourth decade when a barrier to the transport of glutathione forms around the lens nucleus. Consequently, as the lens ages, its transparency falls and the nucleus becomes more rigid, resisting the change in shape necessary for accommodation. This is the basis of presbyopia. In some individuals, the steady accumulation of chromophores and complex, insoluble crystallin aggregates in the lens nucleus leads to the formation of a brown nuclear cataract. The process is homogeneous and the affected lens fibres retain their gross morphology. Cortical opacities are due to changes in membrane permeability and enzyme function and shear-stress damage to lens fibres with continued accommodative effort. Unlike nuclear cataract, progression is intermittent, stepwise and non-uniform. © 2011 The Royal Society.
    Original languageEnglish
    Pages (from-to)1278-1292
    JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
    Volume366
    Issue number1568
    DOIs
    Publication statusPublished - 27 Apr 2011

    Keywords

    • Cortical cataract
    • Lens morphology
    • Light-scattering
    • Nuclear cataract

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