Tetanus toxin-induced protein kinase C activation and elevated serotonin levels in the perinatal rat brain

Jose Aguilera, Lluis A. Lopez, Ephraim Yavin

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

A single intracerebral injection of tetanus toxin (TeTox) is able to produce a time-dependent translocation of Ca2+-phosphatidylserine-dependent protein kinase C (PKC) in close-to-tenn rat brain. TeTox-triggered translocation of PKC is dose- and time-dependent, can be prevented by tetanus antitoxin, and does not occur upon administration of toxin fragments B and C. TeTox-triggered PKC translocation is accompanied by a timedependent increase in brain serotonin (5-HT). Increase of brain 5-HT is independent of monoamine oxidase inhibition by pargyline. Phorbol ester and TeTox cause a significant increase in serotonin while H-7, a kinase inhibitor, does not affect serotonin levels but abolishes the effect of TeTox. Gangliosides prevent TeTox-triggered 5-HT increase. The data are consistent with the possibility that TeTox acts effectively on the serotonergic innervation, presumably in conjunction with PKC to cause accumulation of serotonin. © 1990.
Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalFEBS Letters
Volume263
Issue number1
DOIs
Publication statusPublished - 9 Apr 1990

Keywords

  • Brain development
  • Ganglioside
  • Protein kinase C
  • Serotonin
  • Tetanus toxin

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