Tetanus intoxication causes an increment of serotonin in the central nervous system

J. Aguilera, J. Heredero, F. Gonzalez Sastre

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Mice injected with tetanus toxin (TTx) showed an increase of 5-hydroxytryptamine (serotonin, 5-HT) levels in the central nervous system. The increment was not uniform thoughout the central nervous system. Particularly significant were the 25% and 80% increases observed, respectively, in whole brain and spinal cord. The levels of dopamine and norepinephrine remained unchanged. The subsequent studies of 5-HT turnover revealed a synthesis rate in the tetanic animals that was almost double that of controls. The degradation rate of the amine as well as the levels of 5-hydroxyindolacetic acid were unaffected. © 1987 Birkhäuser Verlag.
Original languageEnglish
Pages (from-to)410-412
JournalExperientia
Volume43
DOIs
Publication statusPublished - 1 Apr 1987

Keywords

  • 5-hydroxytryptamine
  • Serotonin
  • alphamethyldopa
  • indolamine
  • pargyline
  • tetanus toxin

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