Mice injected with tetanus toxin (TTx) showed an increase of 5-hydroxytryptamine (serotonin, 5-HT) levels in the central nervous system. The increment was not uniform thoughout the central nervous system. Particularly significant were the 25% and 80% increases observed, respectively, in whole brain and spinal cord. The levels of dopamine and norepinephrine remained unchanged. The subsequent studies of 5-HT turnover revealed a synthesis rate in the tetanic animals that was almost double that of controls. The degradation rate of the amine as well as the levels of 5-hydroxyindolacetic acid were unaffected. © 1987 Birkhäuser Verlag.
|Publication status||Published - 1 Apr 1987|
- tetanus toxin
Aguilera, J., Heredero, J., & Gonzalez Sastre, F. (1987). Tetanus intoxication causes an increment of serotonin in the central nervous system. Experientia, 43, 410-412. https://doi.org/10.1007/BF01940431