Testosterone deficiency, metabolic syndrome and diabetes mellitus

Mercè Fernández-Miró, Juan J. Chillarón, Juan Pedro-Botet

Research output: Contribution to journalReview articleResearchpeer-review

10 Citations (Scopus)


© 2015 Elsevier España, S.L.U. Testosterone deficiency in adult age is associated with a decrease in libido, energy, hematocrit, muscle mass and bone mineral density, as well as with depression. More recently, testosterone deficiency has also been associated with various components of the metabolic syndrome, which in turn is associated with a five-fold increase in the risk of cardiovascular disease. Low testosterone levels are associated with increased insulin resistance, increase in fat mass, low HDL cholesterol, higher triglyceride levels and hypertension. Testosterone replacement therapy in patients with testosterone deficiency and type 2 diabetes mellitus and/or metabolic syndrome has shown reductions in insulin resistance, total cholesterol, LDL cholesterol and triglycerides and improvement in glycemic control and anthropometric parameters.
Original languageEnglish
Pages (from-to)69-73
JournalMedicina Clinica
Issue number2
Publication statusPublished - 15 Jan 2016


  • Hypogonadism
  • Hypogonadism and diabetes
  • Testosterone deficiency


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